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Des Moines

$110+ Cheap flights from South Carolina to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/29. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
abr. 5 — abr. 121
sáb. 4/5
sáb. 4/12
1 adult, Economy
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Cheap flight deals from South Carolina to Des Moines

Keep the following information in mind while searching for South Carolina to Des Moines flight deals. Data was last updated marzo 31, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$235
(Mytrip)

One-way from

$110
(Booking.com)

Popular in

January

Cheapest in

April
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
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From South Carolina to Des Moines
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One-way flight from South Carolina to Des Moines
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Highest demand for flights based on searches. 19% potential increase in price ($88 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
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Find flight deals from South Carolina to Des Moines

Cheapest flights from South Carolina to Des Moines
Explore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on marzo 31, 2025.

This Mytrip deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/119:46 pmGSP - DSM
1 stop17h 12mAllegiant Air
dom. 4/134:59 pmDSM - GSP
1 stop26h 57mAllegiant Air
Deal found 3/29$235
This Mytrip deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/89:43 amCHS - DSM
2 stops38h 30mMultiple Airlines
lun. 5/121:31 pmDSM - CHS
2 stops31h 38mMultiple Airlines
Deal found 3/29$241
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 6/105:34 pmCLT - DSM
1 stop27h 19mFrontier
sáb. 6/148:38 pmDSM - CLT
1 stop18h 56mFrontier
Deal found 3/31$263
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/21:20 pmCAE - DSM
1 stop5h 19mDelta
lun. 12/812:45 pmDSM - CAE
1 stop8h 37mDelta
Deal found 3/30$269
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/34:19 pmCAE - DSM
2 stops8h 33mAmerican Airlines
mar. 7/87:07 amDSM - CAE
1 stop5h 59mAmerican Airlines
Deal found 3/30$284
This Mytrip deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/1110:57 amCLT - DSM
1 stop12h 24mMultiple Airlines
lun. 4/141:31 pmDSM - CLT
2 stops26h 07mMultiple Airlines
Deal found 3/30$294
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/812:26 pmSAV - DSM
1 stop6h 12mDelta
mié. 7/163:44 pmDSM - SAV
1 stop7h 05mDelta
Deal found 3/30$297
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/36:20 amGSP - DSM
1 stop5h 21mDelta
sáb. 5/106:30 amDSM - GSP
1 stop4h 16mDelta
Deal found 3/31$297
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/299:03 amSAV - DSM
1 stop5h 10mAmerican Airlines
mar. 5/611:51 amDSM - SAV
2 stops7h 03mAmerican Airlines
Deal found 3/30$302
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/35:28 amGSP - DSM
2 stops6h 53mAmerican Airlines
sáb. 5/102:01 pmDSM - GSP
1 stop5h 01mAmerican Airlines
Deal found 3/30$302
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/87:39 amCHS - DSM
1 stop6h 46mDelta
lun. 5/126:35 pmDSM - CHS
1 stop4h 09mDelta
Deal found 3/29$303
This Mytrip deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/119:46 pmGSP - DSM
1 stop17h 12mMultiple Airlines
dom. 4/137:30 amDSM - GSP
2 stops30h 34mMultiple Airlines
Deal found 3/29$337

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated marzo 31, 2025.
Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.

Fly from

South Carolina

Fly to

Des Moines

Route

Depart

Return

Price

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

vie. 4/11

9:46 pm-1:58 pm

1 stop17h 12m

Des Moines

dom. 4/13

4:59 pm-8:56 pm

1 stop26h 57m

$235

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

jue. 5/8

9:43 am-11:13 pm

2 stops38h 30m

Des Moines

lun. 5/12

1:31 pm-10:09 pm

2 stops31h 38m

$241

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

mar. 6/10

5:34 pm-7:53 pm

1 stop27h 19m

Des Moines

sáb. 6/14

8:38 pm-4:34 pm

1 stop18h 56m

$263

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

jue. 7/3

4:19 pm-11:52 pm

2 stops8h 33m

Des Moines

mar. 7/8

7:07 am-2:06 pm

1 stop5h 59m

$284

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

vie. 4/11

10:57 am-10:21 pm

1 stop12h 24m

Des Moines

lun. 4/14

1:31 pm-4:38 pm

2 stops26h 07m

$294

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

mar. 7/8

7:00 am-10:14 am

1 stop4h 14m

Des Moines

mar. 7/15

3:44 pm-11:49 pm

1 stop7h 05m

$297

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

sáb. 5/3

6:20 am-10:41 am

1 stop5h 21m

Des Moines

sáb. 5/10

6:30 am-11:46 am

1 stop4h 16m

$297

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

mar. 4/29

9:03 am-1:13 pm

1 stop5h 10m

Des Moines

mar. 5/6

11:51 am-7:54 pm

2 stops7h 03m

$302

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

sáb. 5/3

5:28 am-11:21 am

2 stops6h 53m

Des Moines

sáb. 5/10

2:01 pm-8:02 pm

1 stop5h 01m

$302

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

jue. 5/8

7:39 am-1:25 pm

1 stop6h 46m

Des Moines

lun. 5/12

6:35 pm-11:44 pm

1 stop4h 09m

$303

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/30

Showing 1-10 of 37 results
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Best time to book a flight from South Carolina to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Des Moines

What is the cheapest month to book a flight from South Carolina to Des Moines?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $336). Flying from South Carolina to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to DSM?

Find hourly flight availability from South Carolina to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated marzo 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Des Moines as you normally would.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated marzo 31, 2025.
See what other customers who have flown with Southwest, Delta and United Airlines from South Carolina to Des Moines have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,276 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Overall

8.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.0
Very good
4,276 reviews
Southwest
8.0
Very good
4,276 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Overall

8.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,899 reviews
Southwest
8.0
Very good
4,276 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Overall

8.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,614 reviews
Southwest
8.0
Very good
4,276 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Overall

8.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Allegiant Air
7.3
Good
731 reviews
Southwest
8.0
Very good
4,276 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Overall

8.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,276 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Overall

8.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from South Carolina?

    Des Moines (DSM) is the airport you will fly into if you book a flight from South Carolina to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • What are the cheapest airlines to fly from South Carolina to Des Moines one-way?

    One-way options have recently been found by users for as low as $110 on Frontier. Other airlines that offer cheap prices include American Airlines from $149 and Southwest from $173 one-way.

  • What are the most popular routes from South Carolina to Des Moines?

    When deciding which route to take from South Carolina to Des Moines consider Charlotte Douglas - Des Moines, Greenville - Des Moines or Charleston - Des Moines as they are the most popular.

  • Can I find deals for flights from South Carolina to Des Moines that include hotel bookings?

    Yes. In addition to deals on South Carolina to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Des Moines.

  • Can I find deals for business class flights from South Carolina to Des Moines?

    Yes. Cheapflights offers flight deals from South Carolina to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $336). Flying from South Carolina to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Ames
Altoona
Johnston
Boone
West Des Moines

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Reagan-National to Cedar Rapids flights
Baltimore to Des Moines flights
Sky Harbor Intl to Des Moines flights
Atlanta to Cedar Rapids flights
San Diego to Omaha flights
Detroit to Des Moines flights
Ontario to Des Moines flights

Top 2 airlines flying from South Carolina to Des Moines

Discover the top 2 airlines that operate flights from South Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated marzo 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$188Average$435FlexibilityNo cancel feeOn-time71%
DeltaCheapest$198Average$386FlexibilityNo cancel feeOn-timeN/A
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