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$81+ Cheap flights from South Carolina to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/17. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from South Carolina to Des Moines

Keep the following information in mind while searching for South Carolina to Des Moines flight deals. Data was last updated February 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$180
(Booking.com)

One-way from

$81
(Frontier)
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
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From South Carolina to Des Moines
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One-way flight from South Carolina to Des Moines
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Find flight deals from South Carolina to Des Moines

Cheapest flights from South Carolina to Des Moines
Explore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This Booking.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/610:31 pmCLT - DSM
1 stop21h 48mFrontier
Fri 4/118:17 pmDSM - CLT
1 stop21h 40mFrontier
Deal found 2/19$180
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2612:11 pmCLT - DSM
Nonstop2h 29mAmerican Airlines
Mon 3/312:07 pmDSM - CLT
Nonstop2h 23mAmerican Airlines
Deal found 2/20$243
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/286:00 amCHS - DSM
1 stop9h 10mDelta
Mon 3/316:30 pmDSM - CHS
1 stop4h 27mDelta
Deal found 2/20$257
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/36:00 amCLT - DSM
1 stop5h 37mDelta
Tue 4/810:22 amDSM - CLT
1 stop4h 37mDelta
Deal found 2/20$263
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/126:34 amSAV - DSM
1 stop7h 39mAmerican Airlines
Tue 4/1512:49 pmDSM - SAV
1 stop8h 06mAmerican Airlines
Deal found 2/20$277
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/712:46 pmCHS - DSM
2 stops7h 35mAmerican Airlines
Tue 3/111:00 pmDSM - CHS
1 stop8h 02mAmerican Airlines
Deal found 2/20$282
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/106:49 pmMYR - DSM
1 stop20h 11mMultiple Airlines
Fri 4/253:25 pmDSM - MYR
2 stops29h 27mMultiple Airlines
Deal found 2/20$295
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/310:52 amGSP - DSM
1 stop7h 14mDelta
Sat 5/106:30 pmDSM - GSP
1 stop4h 13mDelta
Deal found 2/19$297
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/17:00 amSAV - DSM
1 stop8h 37mAllegiant Air
Fri 3/73:54 pmDSM - SAV
1 stop27h 46mAllegiant Air
Deal found 2/20$302
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/36:40 amGSP - DSM
2 stops8h 53mAmerican Airlines
Sat 5/102:20 pmDSM - GSP
1 stop6h 36mAmerican Airlines
Deal found 2/19$302
This Mytrip deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/69:50 pmGSP - DSM
1 stop15h 52mAllegiant Air
Mon 3/107:30 amDSM - GSP
1 stop6h 35mAllegiant Air
Deal found 2/19$333
This United deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/36:36 amCLT - DSM
1 stop5h 04mUnited Airlines
Mon 4/73:34 pmDSM - CLT
2 stops7h 25mUnited Airlines
Deal found 2/20$339

Find flights from South Carolina to Des Moines within your budget

Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

South Carolina

Fly to

Des Moines

Route

Depart

Return

Price

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Sun 4/6

10:31 pm-7:19 pm

1 stop21h 48m

Des Moines

Fri 4/11

8:17 pm-6:57 pm

1 stop21h 40m

$180

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 3/26

12:11 pm-1:40 pm

Nonstop2h 29m

Des Moines

Mon 3/31

2:07 pm-5:30 pm

Nonstop2h 23m

$243

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 3/28

6:00 am-2:10 pm

1 stop9h 10m

Des Moines

Mon 3/31

6:30 pm-11:57 pm

1 stop4h 27m

$257

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 4/3

6:00 am-10:37 am

1 stop5h 37m

Des Moines

Tue 4/8

10:22 am-3:59 pm

1 stop4h 37m

$263

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

Sat 4/12

6:34 am-1:13 pm

1 stop7h 39m

Des Moines

Tue 4/15

12:49 pm-9:55 pm

1 stop8h 06m

$277

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 3/7

12:46 pm-7:21 pm

2 stops7h 35m

Des Moines

Tue 3/11

1:00 pm-10:02 pm

1 stop8h 02m

$282

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 4/10

6:49 pm-2:00 pm

1 stop20h 11m

Des Moines

Fri 4/25

3:25 pm-9:52 pm

2 stops29h 27m

$295

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 5/3

10:52 am-5:06 pm

1 stop7h 14m

Des Moines

Sat 5/10

6:30 pm-11:43 pm

1 stop4h 13m

$297

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 5/3

6:40 am-2:33 pm

2 stops8h 53m

Des Moines

Sat 5/10

2:20 pm-9:56 pm

1 stop6h 36m

$302

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 3/6

9:50 pm-12:42 pm

1 stop15h 52m

Des Moines

Mon 3/10

7:30 am-3:05 pm

1 stop6h 35m

$333

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Showing 1-10 of 38 results
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Best time to book a flight from South Carolina to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from South Carolina to Des Moines

Get recent, data-driven insights about flights from South Carolina to Des Moines including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from South Carolina to Des Moines?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $336). Flying from South Carolina to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to DSM?

Find hourly flight availability from South Carolina to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Des Moines as you normally would.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated February 20, 2025.
See what other customers who have flown with Southwest, Delta and United Airlines from South Carolina to Des Moines have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,411 reviews

Food

7.1

Crew

8.7

Entertainment

7.6

Boarding

8.2

Comfort

8.1

Overall

8.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Southwest
8.1
Very good
4,411 reviews
Southwest
8.1
Very good
4,411 reviews

Food

7.1

Crew

8.7

Entertainment

7.6

Boarding

8.2

Comfort

8.1

Overall

8.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Delta
8.0
Very good
8,219 reviews
Southwest
8.1
Very good
4,411 reviews

Food

7.1

Crew

8.7

Entertainment

7.6

Boarding

8.2

Comfort

8.1

Overall

8.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

United Airlines
7.4
Good
8,765 reviews
Southwest
8.1
Very good
4,411 reviews

Food

7.1

Crew

8.7

Entertainment

7.6

Boarding

8.2

Comfort

8.1

Overall

8.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Allegiant Air
7.3
Good
765 reviews
Southwest
8.1
Very good
4,411 reviews

Food

7.1

Crew

8.7

Entertainment

7.6

Boarding

8.2

Comfort

8.1

Overall

8.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,411 reviews

Food

7.1

Crew

8.7

Entertainment

7.6

Boarding

8.2

Comfort

8.1

Overall

8.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from South Carolina?

    Des Moines (DSM) is the airport you will fly into if you book a flight from South Carolina to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • What are the cheapest airlines to fly from South Carolina to Des Moines one-way?

    One-way options have recently been found by users for as low as $81 on Frontier. Other airlines that offer cheap prices include American Airlines from $127 and Delta from $132 one-way.

  • What are the most popular routes from South Carolina to Des Moines?

    When deciding which route to take from South Carolina to Des Moines consider Charlotte Douglas - Des Moines, Greenville - Des Moines or Columbia Metropolitan - Des Moines as they are the most popular.

  • Can I find deals for flights from South Carolina to Des Moines that include hotel bookings?

    Yes. In addition to deals on South Carolina to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Des Moines.

  • Can I find deals for business class flights from South Carolina to Des Moines?

    Yes. Cheapflights offers flight deals from South Carolina to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $336). Flying from South Carolina to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Ames
Altoona
Johnston
Boone
West Des Moines

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Alternative routes for South Carolina to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Des Moines

Discover the top 2 airlines that operate flights from South Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$188Average$424FlexibilityNo cancel feeOn-time71%
DeltaCheapest$198Average$372FlexibilityNo cancel feeOn-timeN/A
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