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Des Moines

$118+ Cheap flights from South Carolina to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/16. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Apr 29 — May 61
Tue 4/29
Tue 5/6
1 adult, Economy
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Cheap flight deals from South Carolina to Des Moines

Keep the following information in mind while searching for South Carolina to Des Moines flight deals. Data was last updated April 24, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$211
(Mytrip)

One-way from

$118
(Mytrip)
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
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From South Carolina to Des Moines
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One-way flight from South Carolina to Des Moines
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Find flight deals from South Carolina to Des Moines

Cheapest flights from South Carolina to Des Moines
Explore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.

This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/135:33 pmCLT - DSM
1 stop4h 51mMultiple Airlines
Sun 6/156:32 pmDSM - CLT
1 stop21h 05mMultiple Airlines
Deal found 4/22$204
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2111:15 amCLT - DSM
2 stops11h 50mSouthwest
Wed 5/285:40 amDSM - CLT
1 stop6h 40mSouthwest
Deal found 4/23$278
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/145:24 amCAE - DSM
1 stop7h 57mAmerican Airlines
Sat 5/1712:50 pmDSM - CAE
2 stops8h 04mAmerican Airlines
Deal found 4/23$299
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/139:23 pmGSP - DSM
2 stops20h 55mMultiple Airlines
Sun 6/153:48 pmDSM - GSP
1 stop15h 58mMultiple Airlines
Deal found 4/22$299
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/76:39 pmGSP - DSM
1 stop3h 57mAmerican Airlines
Wed 8/137:07 amDSM - GSP
1 stop7h 08mAmerican Airlines
Deal found 4/24$300
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/139:36 amGSP - DSM
1 stop27h 49mAllegiant Air
Sun 6/153:48 pmDSM - GSP
1 stop15h 58mAllegiant Air
Deal found 4/22$311
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/39:43 amCHS - DSM
1 stop6h 17mDelta
Sun 7/67:00 amDSM - CHS
1 stop6h 08mDelta
Deal found 4/22$319
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/37:59 pmCHS - DSM
1 stop4h 53mAmerican Airlines
Sun 7/65:17 pmDSM - CHS
1 stop5h 39mAmerican Airlines
Deal found 4/23$326
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/115:45 amAGS - DSM
1 stop5h 54mDelta
Sat 6/145:40 amDSM - AGS
1 stop4h 47mDelta
Deal found 4/22$327
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/124:45 pmSAV - DSM
1 stop6h 02mUnited Airlines
Fri 7/188:00 amDSM - SAV
1 stop5h 34mUnited Airlines
Deal found 4/23$332
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/115:00 amAGS - DSM
2 stops8h 29mAmerican Airlines
Sat 6/145:32 pmDSM - AGS
1 stop5h 27mAmerican Airlines
Deal found 4/22$332
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/57:02 pmSAV - DSM
1 stop6h 04mAmerican Airlines
Sun 6/85:32 pmDSM - SAV
1 stop5h 20mAmerican Airlines
Deal found 4/23$335

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.

Fly from

South Carolina

Fly to

Des Moines

Route

Depart

Return

Price

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Fri 6/13

5:33 pm-9:24 pm

1 stop4h 51m

Des Moines

Sun 6/15

6:32 pm-4:37 pm

1 stop21h 05m

$204

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 5/21

11:15 am-10:05 pm

2 stops11h 50m

Des Moines

Wed 5/28

5:40 am-1:20 pm

1 stop6h 40m

$278

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Wed 5/14

5:24 am-12:21 pm

1 stop7h 57m

Des Moines

Sat 5/17

12:50 pm-9:54 pm

2 stops8h 04m

$299

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Fri 6/13

9:23 pm-5:18 pm

2 stops20h 55m

Des Moines

Sun 6/15

3:48 pm-8:46 am

1 stop15h 58m

$299

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 8/7

6:39 pm-9:36 pm

1 stop3h 57m

Des Moines

Wed 8/13

7:07 am-3:15 pm

1 stop7h 08m

$300

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Fri 6/13

9:36 am-12:25 pm

1 stop27h 49m

Des Moines

Sun 6/15

3:48 pm-8:46 am

1 stop15h 58m

$311

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 7/3

9:43 am-3:00 pm

1 stop6h 17m

Des Moines

Sun 7/6

7:00 am-2:08 pm

1 stop6h 08m

$319

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 7/3

7:59 pm-11:52 pm

1 stop4h 53m

Des Moines

Sun 7/6

5:17 pm-11:56 pm

1 stop5h 39m

$326

AugustaDes Moines

AGS - DSM

AGSDSM

Augusta Bush Field

Wed 6/11

5:45 am-10:39 am

1 stop5h 54m

Des Moines

Sat 6/14

5:40 am-11:27 am

1 stop4h 47m

$327

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

Sat 7/12

4:45 pm-9:47 pm

1 stop6h 02m

Des Moines

Fri 7/18

8:00 am-2:34 pm

1 stop5h 34m

$332

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/22

Showing 1-10 of 45 results
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Best time to book a flight from South Carolina to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Des Moines

What is the cheapest month to book a flight from South Carolina to Des Moines?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $336). Flying from South Carolina to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to DSM?

Find hourly flight availability from South Carolina to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 24, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Des Moines as you normally would.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 24, 2025.
See what other customers who have flown with Southwest, Delta and United Airlines from South Carolina to Des Moines have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,286 reviews

Comfort

8.0

Food

7.1

Boarding

8.2

Crew

8.6

Overall

8.0

Entertainment

7.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,286 reviews
Southwest
8.0
Very good
4,286 reviews

Comfort

8.0

Food

7.1

Boarding

8.2

Crew

8.6

Overall

8.0

Entertainment

7.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,920 reviews
Southwest
8.0
Very good
4,286 reviews

Comfort

8.0

Food

7.1

Boarding

8.2

Crew

8.6

Overall

8.0

Entertainment

7.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,685 reviews
Southwest
8.0
Very good
4,286 reviews

Comfort

8.0

Food

7.1

Boarding

8.2

Crew

8.6

Overall

8.0

Entertainment

7.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Allegiant Air
7.3
Good
734 reviews
Southwest
8.0
Very good
4,286 reviews

Comfort

8.0

Food

7.1

Boarding

8.2

Crew

8.6

Overall

8.0

Entertainment

7.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,286 reviews

Comfort

8.0

Food

7.1

Boarding

8.2

Crew

8.6

Overall

8.0

Entertainment

7.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from South Carolina?

    Des Moines (DSM) is the airport you will fly into if you book a flight from South Carolina to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • What are the cheapest airlines to fly from South Carolina to Des Moines one-way?

    One-way options have recently been found by users for as low as $136 on American Airlines. Other airlines that offer cheap prices include Delta from $149 and Southwest from $149 one-way.

  • What are the most popular routes from South Carolina to Des Moines?

    When deciding which route to take from South Carolina to Des Moines consider Charlotte Douglas - Des Moines, Savannah/Hilton Head - Des Moines or Columbia Metropolitan - Des Moines as they are the most popular.

  • Can I find deals for flights from South Carolina to Des Moines that include hotel bookings?

    Yes. In addition to deals on South Carolina to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Des Moines.

  • Can I find deals for business class flights from South Carolina to Des Moines?

    Yes. Cheapflights offers flight deals from South Carolina to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $336). Flying from South Carolina to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Ames
Altoona
Johnston
Boone
West Des Moines
Ankeny

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Alternative routes for South Carolina to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Des Moines

Discover the top 2 airlines that operate flights from South Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$188Average$435FlexibilityNo cancel feeOn-time71%
DeltaCheapest$198Average$404FlexibilityNo cancel feeOn-timeN/A

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