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Des Moines

$100+ Cheap flights from South Carolina to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/20. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Jan 26 — Feb 21
Sun 1/26
Sun 2/2
1 adult, Economy
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Cheap flight deals from South Carolina to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from South Carolina (USSC) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2025.

Round-trip from

$290
(Mytrip)

One-way from

$100
(CheapOair)
From South Carolina to Des Moines
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One-way flight from South Carolina to Des Moines
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Find flight deals from South Carolina to Des Moines

Cheapest flights from South Carolina to Des Moines
Explore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2025.

This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/127:00 amGSP - DSM
1 stop4h 40mDelta
Tue 3/1810:22 amDSM - GSP
1 stop6h 11mDelta
Deal found 1/21$297
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/137:00 amGSP - DSM
1 stop6h 19mAmerican Airlines
Mon 3/242:52 pmDSM - GSP
2 stops7h 48mAmerican Airlines
Deal found 1/21$302
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1311:58 amCLT - DSM
Nonstop2h 30mAmerican Airlines
Tue 2/186:35 amDSM - CLT
Nonstop2h 22mAmerican Airlines
Deal found 1/21$325
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/54:45 pmCAE - DSM
1 stop6h 07mUnited Airlines
Sun 2/98:00 amDSM - CAE
1 stop5h 06mUnited Airlines
Deal found 1/21$329
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/236:35 amCHS - DSM
1 stop6h 46mAmerican Airlines
Tue 2/255:50 amDSM - CHS
1 stop4h 42mAmerican Airlines
Deal found 1/20$332
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/52:32 pmCAE - DSM
2 stops8h 36mAmerican Airlines
Sun 2/95:55 amDSM - CAE
2 stops8h 49mAmerican Airlines
Deal found 1/20$335
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1411:59 amCLT - DSM
1 stop6h 39mDelta
Wed 5/212:14 pmDSM - CLT
1 stop4h 05mDelta
Deal found 1/21$343
This FlightHub deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/155:06 pmCLT - DSM
1 stop26h 24mFrontier
Wed 5/217:20 pmDSM - CLT
1 stop19h 56mFrontier
Deal found 1/20$350
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/51:08 pmMYR - DSM
1 stop6h 53mDelta
Sun 2/96:30 amDSM - MYR
1 stop4h 41mDelta
Deal found 1/21$362
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/126:00 amGSP - DSM
2 stops9h 32mUnited Airlines
Mon 3/173:25 pmDSM - GSP
1 stop4h 21mUnited Airlines
Deal found 1/21$372
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/55:05 amMYR - DSM
2 stops8h 06mAmerican Airlines
Sun 2/912:15 pmDSM - MYR
2 stops9h 13mAmerican Airlines
Deal found 1/21$372
This Southwest deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1310:55 amCLT - DSM
2 stops13h 40mSouthwest
Tue 2/186:10 amDSM - CLT
2 stops11h 15mSouthwest
Deal found 1/21$390

Find flights from South Carolina to Des Moines within your budget

Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 3/12

6:00 am-2:10 pm

1 stop9h 10m

Des Moines

Mon 3/17

6:30 pm-11:57 pm

1 stop4h 27m

$257

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 3/12

7:00 am-10:40 am

1 stop4h 40m

Des Moines

Tue 3/18

10:22 am-5:33 pm

1 stop6h 11m

$297

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 3/13

7:00 am-12:19 pm

1 stop6h 19m

Des Moines

Mon 3/24

2:52 pm-11:40 pm

2 stops7h 48m

$302

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 3/12

10:48 am-5:33 pm

1 stop7h 45m

Des Moines

Mon 3/17

1:32 pm-1:09 pm

3 stops22h 37m

$327

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Wed 2/5

4:45 pm-9:52 pm

1 stop6h 07m

Des Moines

Sun 2/9

8:00 am-2:06 pm

1 stop5h 06m

$329

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 3/13

8:30 pm-10:04 pm

Nonstop2h 34m

Des Moines

Mon 3/17

5:29 pm-12:33 am

1 stop6h 04m

$335

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Wed 2/5

2:32 pm-10:08 pm

2 stops8h 36m

Des Moines

Sun 2/9

5:55 am-3:44 pm

2 stops8h 49m

$335

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Tue 2/4

2:20 pm-5:36 pm

1 stop4h 16m

Des Moines

Sat 2/8

4:15 pm-11:41 pm

1 stop6h 26m

$343

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 5/15

5:06 pm-6:30 pm

1 stop26h 24m

Des Moines

Wed 5/21

7:20 pm-4:16 pm

1 stop19h 56m

$350

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Sun 2/23

6:35 am-12:21 pm

1 stop6h 46m

Des Moines

Tue 2/25

6:35 am-2:22 pm

1 stop6h 47m

$352

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Showing 1-10 of 38 results
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Best time to book a flight from South Carolina to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from South Carolina to Des Moines

Get recent, data-driven insights about flights from South Carolina to Des Moines including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from South Carolina to Des Moines?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $336). Flying from South Carolina to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to DSM?

Find hourly flight availability from South Carolina to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 21, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Des Moines as you normally would.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated January 21, 2025.
See what other customers who have flown with Delta, American Airlines and Southwest from South Carolina to Des Moines have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,662 reviews

Overall

8.1

Comfort

8.1

Boarding

8.2

Food

7.2

Crew

8.7

Entertainment

7.7

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Southwest
8.1
Very good
4,662 reviews
Southwest
8.1
Very good
4,662 reviews

Overall

8.1

Comfort

8.1

Boarding

8.2

Food

7.2

Crew

8.7

Entertainment

7.7

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Delta
8.0
Very good
8,521 reviews
Southwest
8.1
Very good
4,662 reviews

Overall

8.1

Comfort

8.1

Boarding

8.2

Food

7.2

Crew

8.7

Entertainment

7.7

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

United Airlines
7.4
Good
8,984 reviews
Southwest
8.1
Very good
4,662 reviews

Overall

8.1

Comfort

8.1

Boarding

8.2

Food

7.2

Crew

8.7

Entertainment

7.7

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,662 reviews

Overall

8.1

Comfort

8.1

Boarding

8.2

Food

7.2

Crew

8.7

Entertainment

7.7

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Frontier
6.1
Okay
3,443 reviews
Southwest
8.1
Very good
4,662 reviews

Overall

8.1

Comfort

8.1

Boarding

8.2

Food

7.2

Crew

8.7

Entertainment

7.7

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from South Carolina?

    Des Moines (DSM) is the airport you will fly into if you book a flight from South Carolina to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • What are the cheapest airlines to fly from South Carolina to Des Moines one-way?

    One-way options have recently been found by users for as low as $100 on Frontier. Other airlines that offer cheap prices include American Airlines from $149 and Southwest from $154 one-way.

  • What are the most popular routes from South Carolina to Des Moines?

    When deciding which route to take from South Carolina to Des Moines consider Charlotte Douglas - Des Moines, Greenville - Des Moines or Charleston - Des Moines as they are the most popular.

  • Can I find deals for flights from South Carolina to Des Moines that include hotel bookings?

    Yes. In addition to deals on South Carolina to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Des Moines.

  • Can I find deals for business class flights from South Carolina to Des Moines?

    Yes. Cheapflights offers flight deals from South Carolina to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $336). Flying from South Carolina to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Ames
Altoona
Johnston
Boone
West Des Moines

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Alternative routes for South Carolina to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Des Moines

Discover the top 2 airlines that operate flights from South Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$188Average$434FlexibilityNo cancel feeOn-time71%
DeltaCheapest$198Average$372FlexibilityNo cancel feeOn-timeN/A
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