What are the cheapest airlines to fly from North Carolina to Des Moines one-way?

$123 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $149 and $149, respectively.

What are the most popular routes from North Carolina to Des Moines?

When deciding which route to take from North Carolina to Des Moines consider Charlotte Douglas - Des Moines, Asheville Regional - Des Moines or Raleigh-Durham - Des Moines as they are the most popular.

What are the cheapest flights from North Carolina to Des Moines?

Looking for the cheapest flight from North Carolina to Des Moines? While on average our users pay $300, our data indicates the cheapest price to be $121. The most popular route (Charlotte Douglas - Des Moines), is priced around $254.

What are the most popular airlines that fly from North Carolina to Des Moines?

Consider American Airlines, Delta or United Airlines when booking your flight. These represent the most popular airlines when flying from North Carolina to Des Moines.

How far in advance should I book a flight from North Carolina to Des Moines?

To save up to 85% on this flight, we recommend booking at least 44 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from North Carolina to Des Moines from $342 1-2 weeks out and tickets from $501 for flights departing within the next 72 hours.

What is the cheapest month to fly from North Carolina to Des Moines?

Due to multiple factors, expect to potentially pay more when booking in June. For low rates, September can be a great choice for travel to Des Moines. Flights to Des Moines from North Carolina in September are about $424 on average during September, but can be found for as low as $262.

What airport do you fly into for flights to Des Moines from North Carolina?

Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly into when you book flights from North Carolina to Des Moines.

Can I find deals for flights from North Carolina to Des Moines that include hotel bookings?

Yes. In addition to deals on North Carolina to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from North Carolina to Des Moines?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from North Carolina to Des Moines.

Can I find deals for business class flights from North Carolina to Des Moines?

Yes. Cheapflights offers flight deals from North Carolina to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$123+ Flights from North Carolina to Des Moines

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Cheap flight deals from North Carolina to Des Moines

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$224 (American Airlines)
One-way from	$123 (Mytrip)
Popular in	June
Cheapest in	September
Average price	$447
Good round-trip deal	$243 or less
Good one-way deal	$178 or less

Provider with most accurate pricing for Charlotte Douglas-Des Moines flight deals.

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Provider most trusted by Cheapflights users for Charlotte Douglas-Des Moines flights.

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From North Carolina to Des Moines

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One-way flight from North Carolina to Des Moines

Search Deals

Highest demand for flights based on searches. 4% potential increase in price ($21 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in March 2025

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Price to beat on a round-trip flight from North Carolina to Des Moines.

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Price to beat on a one-way flight from North Carolina to Des Moines.

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Find flight deals from North Carolina to Des Moines

Cheapest flights from North Carolina to Des Moines
Explore the most affordable flight options available from North Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.

Wed 7/26:01 pmGSO - DSM

1 stop6h 48mAmerican Airlines

Tue 7/87:07 amDSM - GSO

1 stop6h 03mAmerican Airlines

Deal found 3/27

$224

Sat 5/2410:27 pmCLT - DSM

Nonstop2h 31mAmerican Airlines

Wed 5/286:45 amDSM - CLT

Nonstop2h 20mAmerican Airlines

Deal found 3/26

$243

Wed 6/1112:41 pmAVL - DSM

1 stop7h 32mDelta

Wed 6/186:31 pmDSM - AVL

1 stop4h 19mDelta

Deal found 3/26

$249

Fri 5/27:00 amTYS - DSM

1 stop4h 30mUnited Airlines

Mon 5/53:34 pmDSM - TYS

1 stop6h 11mUnited Airlines

Deal found 3/26

$249

Thu 4/2412:40 pmGSO - DSM

1 stop5h 26mDelta

Mon 4/284:45 pmDSM - GSO

1 stop4h 18mDelta

Deal found 3/26

$249

Fri 4/49:58 pmAVL - DSM

1 stop24h 53mAllegiant Air

Sun 4/61:27 pmDSM - AVL

1 stop21h 58mAllegiant Air

Deal found 3/27

$251

Wed 8/275:18 amTYS - DSM

2 stops6h 54mAmerican Airlines

Sat 8/307:20 amDSM - TYS

1 stop7h 25mAmerican Airlines

Deal found 3/27

$254

Wed 9/33:57 pmCLT - DSM

2 stops25h 28mMultiple Airlines

Fri 9/58:25 amDSM - CLT

1 stop28h 31mMultiple Airlines

Deal found 3/27

$281

Fri 5/210:00 amTYS - DSM

2 stops14h 13mMultiple Airlines

Mon 5/56:00 amDSM - TYS

1 stop27h 36mMultiple Airlines

Deal found 3/26

$281

Wed 4/22:15 pmAVL - DSM

1 stop5h 56mAmerican Airlines

Wed 4/912:49 pmDSM - AVL

2 stops10h 01mAmerican Airlines

Deal found 3/26

$289

Wed 8/206:11 pmORF - DSM

1 stop4h 25mAmerican Airlines

Tue 8/262:39 pmDSM - ORF

1 stop6h 07mAmerican Airlines

Deal found 3/27

$297

Tue 4/228:00 amRDU - DSM

1 stop4h 35mSouthwest

Thu 4/245:30 pmDSM - RDU

1 stop3h 55mSouthwest

Deal found 3/27

$297

Best flights from North Carolina to Des Moines
Discover carefully curated flight deals from North Carolina to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 28, 2025.

Wed 7/26:01 pmGSO - DSM

1 stop6h 48mAmerican Airlines

Tue 7/87:07 amDSM - GSO

1 stop6h 03mAmerican Airlines

Deal found 3/27

$224

Wed 6/1112:41 pmAVL - DSM

1 stop7h 32mDelta

Wed 6/186:31 pmDSM - AVL

1 stop4h 19mDelta

Deal found 3/26

$249

Fri 5/27:00 amTYS - DSM

1 stop4h 30mUnited Airlines

Mon 5/53:34 pmDSM - TYS

1 stop6h 11mUnited Airlines

Deal found 3/26

$249

Wed 9/33:57 pmCLT - DSM

2 stops25h 28mMultiple Airlines

Fri 9/58:25 amDSM - CLT

1 stop28h 31mMultiple Airlines

Deal found 3/27

$281

Tue 4/228:00 amRDU - DSM

1 stop4h 35mSouthwest

Thu 4/245:30 pmDSM - RDU

1 stop3h 55mSouthwest

Deal found 3/27

$297

Sat 5/2410:27 pmCLT - DSM

Nonstop2h 31mAmerican Airlines

Wed 5/286:45 amDSM - CLT

Nonstop2h 20mAmerican Airlines

Deal found 3/26

$243

Thu 4/2412:40 pmGSO - DSM

1 stop5h 26mDelta

Mon 4/284:45 pmDSM - GSO

1 stop4h 18mDelta

Deal found 3/26

$249

Wed 8/275:18 amTYS - DSM

2 stops6h 54mAmerican Airlines

Sun 8/316:00 amDSM - TYS

1 stop5h 24mAmerican Airlines

Deal found 3/27

$254

Fri 5/210:00 amTYS - DSM

2 stops14h 13mMultiple Airlines

Mon 5/56:00 amDSM - TYS

1 stop27h 36mMultiple Airlines

Deal found 3/26

$281

Fri 5/304:20 pmCLT - DSM

1 stop7h 45mSouthwest

Tue 6/35:40 amDSM - CLT

2 stops8h 10mSouthwest

Deal found 3/25

$315

Mon 4/286:05 amRDU - DSM

1 stop5h 35mUnited Airlines

Thu 5/111:26 amDSM - RDU

2 stops11h 20mUnited Airlines

Deal found 3/27

$354

Wed 8/206:11 pmORF - DSM

1 stop4h 25mAmerican Airlines

Tue 8/262:39 pmDSM - ORF

1 stop6h 07mAmerican Airlines

Deal found 3/27

$297

Last-minute flights from North Carolina to Des Moines
Discover last-minute flight deals from North Carolina to Des Moines. Data last updated March 28, 2025 and is based on user searches.

Wed 4/21:04 pmAVL - DSM

1 stop7h 05mDelta

Wed 4/95:45 amDSM - AVL

1 stop6h 03mDelta

Deal found 3/25

$284

Wed 4/22:15 pmAVL - DSM

1 stop5h 56mAmerican Airlines

Wed 4/912:49 pmDSM - AVL

2 stops10h 01mAmerican Airlines

Deal found 3/26

$289

Wed 4/212:05 pmCLT - DSM

2 stops11h 25mSouthwest

Thu 4/35:45 amDSM - CLT

2 stops13h 20mSouthwest

Deal found 3/26

$534

Thu 4/35:20 amRDU - DSM

1 stop6h 17mDelta

Mon 4/76:35 pmDSM - RDU

1 stop4h 24mDelta

Deal found 3/27

$647

Thu 4/38:00 amRDU - DSM

1 stop9h 14mUnited Airlines

Mon 4/711:38 amDSM - RDU

2 stops11h 19mUnited Airlines

Deal found 3/27

$652

Fri 4/49:58 pmAVL - DSM

1 stop24h 53mAllegiant Air

Sun 4/61:27 pmDSM - AVL

1 stop21h 58mAllegiant Air

Deal found 3/27

$251

Fri 4/47:00 amCLT - DSM

1 stop9h 00mMultiple Airlines

Mon 4/71:31 pmDSM - CLT

2 stops25h 59mMultiple Airlines

Deal found 3/26

$346

Fri 4/44:56 pmRDU - DSM

2 stops29h 55mMultiple Airlines

Mon 4/77:30 amDSM - RDU

1 stop25h 33mMultiple Airlines

Deal found 3/26

$347

Fri 4/411:59 amCLT - DSM

Nonstop2h 14mAmerican Airlines

Sun 4/65:43 amDSM - CLT

1 stop4h 50mAmerican Airlines

Deal found 3/25

$485

Fri 4/46:04 amCLT - DSM

1 stop4h 33mDelta

Sun 4/611:55 amDSM - CLT

1 stop5h 55mDelta

Deal found 3/25

$495

Fri 4/46:00 amCLT - DSM

2 stops9h 38mUnited Airlines

Sun 4/68:00 amDSM - CLT

1 stop6h 48mUnited Airlines

Deal found 3/25

$570

Fri 4/41:15 pmRDU - DSM

1 stop9h 34mAmerican Airlines

Mon 4/712:25 pmDSM - RDU

1 stop8h 00mAmerican Airlines

Deal found 3/26

$641

One-way flights from North Carolina to Des Moines
Search for one-way flight options from North Carolina to Des Moines. Find affordable one-way fares based on user searches. Data last updated March 28, 2025.

Fri 4/43:19 pmGSO - DSM

1 stop7h 59mAllegiant Air

Deal found 3/27

$123

Mon 4/286:58 amCLT - DSM

1 stop16h 57mMultiple Airlines

Deal found 3/26

$146

Sat 7/56:00 amORF - DSM

1 stop4h 38mDelta

Deal found 3/26

$149

Wed 6/182:42 pmRDU - DSM

1 stop5h 36mAmerican Airlines

Deal found 3/27

$149

Wed 6/186:00 amRDU - DSM

2 stops9h 42mUnited Airlines

Deal found 3/27

$180

Mon 4/288:39 pmCLT - DSM

Nonstop2h 28mAmerican Airlines

Deal found 3/26

$198

Mon 4/147:45 amRDU - DSM

2 stops16h 23mMultiple Airlines

Deal found 3/27

$204

Sat 7/56:00 amORF - DSM

2 stops10h 30mSouthwest

Deal found 3/26

$214

Sat 4/126:36 amCLT - DSM

2 stops10h 33mUnited Airlines

Deal found 3/27

$247

Sat 7/510:31 amORF - DSM

2 stops8h 18mUnited Airlines

Deal found 3/27

$314

Fri 4/45:15 amGSO - DSM

2 stops7h 40mAmerican Airlines

Deal found 3/27

$345

Fri 4/46:00 amGSO - DSM

3 stops16h 52mUnited Airlines

Deal found 3/27

$1,013

Cheapflights Fare Finder

Use the filters below to find and compare flights from North Carolina to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreensboroDes Moines

GSO - DSM

GSODSM

Greensboro/H. Point

Wed 7/2

6:01 pm-11:49 pm

1 stop6h 48m

Des Moines

Tue 7/8

7:07 am-2:10 pm

1 stop6h 03m

$224

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Sat 5/24

10:27 pm-11:58 pm

Nonstop2h 31m

Des Moines

Wed 5/28

6:45 am-10:05 am

Nonstop2h 20m

$243

AshevilleDes Moines

AVL - DSM

AVLDSM

Asheville Regional

Wed 6/11

12:41 pm-7:13 pm

1 stop7h 32m

Des Moines

Wed 6/18

6:31 pm-11:50 pm

1 stop4h 19m

$249

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 5/2

7:00 am-10:30 am

1 stop4h 30m

Des Moines

Mon 5/5

3:34 pm-10:45 pm

1 stop6h 11m

$249

GreensboroDes Moines

GSO - DSM

GSODSM

Greensboro/H. Point

Thu 4/24

12:40 pm-5:06 pm

1 stop5h 26m

Des Moines

Mon 4/28

4:45 pm-10:03 pm

1 stop4h 18m

$249

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 8/27

5:18 am-11:12 am

2 stops6h 54m

Des Moines

Sat 8/30

7:20 am-3:45 pm

1 stop7h 25m

$254

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 9/3

3:57 pm-4:25 pm

2 stops25h 28m

Des Moines

Fri 9/5

8:25 am-1:56 pm

1 stop28h 31m

$281

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 5/2

10:00 am-11:13 pm

2 stops14h 13m

Des Moines

Mon 5/5

6:00 am-10:36 am

1 stop27h 36m

$281

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Tue 4/22

8:00 am-11:35 am

1 stop4h 35m

Des Moines

Thu 4/24

5:30 pm-10:25 pm

1 stop3h 55m

$297

NorfolkDes Moines

ORF - DSM

ORFDSM

Norfolk

Wed 8/20

6:11 pm-9:36 pm

1 stop4h 25m

Des Moines

Tue 8/26

2:39 pm-9:46 pm

1 stop6h 07m

$297

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/27

Showing 1-10 of 42 results

...

Best time to book a flight from North Carolina to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from North Carolina with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from North Carolina to Des Moines

What is the cheapest month to book a flight from North Carolina to Des Moines?

Currently, August is the cheapest month in which you can book a flight from North Carolina to Des Moines (average of $336). Flying from North Carolina to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from NC to DSM?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from North Carolina to Des Moines as you normally would.

Rainfall in Des Moines by month

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Peruse reviews from past customers who have flown with Southwest, Delta and United Airlines from North Carolina to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.1

Very good

4,273 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Southwest

8.1

Very good

4,273 reviews

Southwest

8.1

Very good

4,273 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Delta

8.0

Very good

7,896 reviews

Southwest

8.1

Very good

4,273 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

United Airlines

7.4

Good

8,603 reviews

Southwest

8.1

Very good

4,273 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Allegiant Air

7.3

Good

731 reviews

Southwest

8.1

Very good

4,273 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

American Airlines

7.2

Good

10,000 reviews

Southwest

8.1

Very good

4,273 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

What airport do you fly into for flights to Des Moines from North Carolina?
Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly into when you book flights from North Carolina to Des Moines.
What are the cheapest airlines to fly from North Carolina to Des Moines one-way?
$123 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $149 and $149, respectively.
What are the most popular routes from North Carolina to Des Moines?
When deciding which route to take from North Carolina to Des Moines consider Charlotte Douglas - Des Moines, Asheville Regional - Des Moines or Raleigh-Durham - Des Moines as they are the most popular.
What are the cheapest flights from North Carolina to Des Moines?
Looking for the cheapest flight from North Carolina to Des Moines? While on average our users pay $300, our data indicates the cheapest price to be $121. The most popular route (Charlotte Douglas - Des Moines), is priced around $254.
Can I find deals for flights from North Carolina to Des Moines that include hotel bookings?
Yes. In addition to deals on North Carolina to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from North Carolina to Des Moines?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from North Carolina to Des Moines.
Can I find deals for business class flights from North Carolina to Des Moines?
Yes. Cheapflights offers flight deals from North Carolina to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from North Carolina to Des Moines?
Currently, August is the cheapest month in which you can book a flight from North Carolina to Des Moines (average of $336). Flying from North Carolina to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Ames

Altoona

Johnston

Boone

West Des Moines

Browse thousands of different options on Cheapflights for your next trip

Top 4 airlines flying from North Carolina to Des Moines

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$227	Average$383	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$238	Average$425	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$248	Average$470	FlexibilityNo cancel fee	On-time69%
Southwest	Cheapest$296	Average$376	FlexibilityNo cancel fee	On-time63%

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$123+ Cheap flights from North Carolina to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/4. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from North Carolina to Des Moines with Cheapflights

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Cheap flight deals from North Carolina to Des Moines

Keep the following information in mind while searching for North Carolina to Des Moines flight deals. Data was last updated March 28, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from North Carolina to Des Moines

Cheapest flights from North Carolina to Des MoinesExplore the most affordable flight options available from North Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.

Explore the most affordable flight options available from North Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from North Carolina to Des Moines that are best for you.

Best time to book a flight from North Carolina to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from North Carolina with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from North Carolina to Des Moines

What is the cheapest month to book a flight from North Carolina to Des Moines?

What is the cheapest time of day to fly from NC to DSM?

Find hourly flight availability from North Carolina to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2025.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

Reviews of airlines servicing Des Moines

Peruse reviews from past customers who have flown with Southwest, Delta and United Airlines from North Carolina to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from North Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Des Moines from North Carolina?

What are the cheapest airlines to fly from North Carolina to Des Moines one-way?

What are the most popular routes from North Carolina to Des Moines?

What are the cheapest flights from North Carolina to Des Moines?

Can I find deals for flights from North Carolina to Des Moines that include hotel bookings?

How can I find direct flights from North Carolina to Des Moines?

Can I find deals for business class flights from North Carolina to Des Moines?

What is the cheapest month to book a flight from North Carolina to Des Moines?

Traveling to a place near North Carolina?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for North Carolina to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from North Carolina to Des Moines

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Cheapest flights from North Carolina to Des Moines
Explore the most affordable flight options available from North Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.