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Des Moines

$115+ Cheap flights from Mississippi to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — DSM
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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Cheap flight deals from Mississippi to Des Moines

Keep the following information in mind while searching for Mississippi to Des Moines flight deals. Data was last updated April 17, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$242
(Delta)

One-way from

$115
(American Airlines)

Popular in

March

Cheapest in

January

Average price

$429
Provider with most accurate pricing for Jackson-Evers Intl-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Jackson-Evers Intl-Des Moines flights.
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From Mississippi to Des Moines
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One-way flight from Mississippi to Des Moines
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Highest demand for flights based on searches. 24% potential increase in price ($154 potential increase over avg. RT price).
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Cheapest flight prices on average. 17% potential price decrease ($70 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Mississippi to Des Moines

Cheapest flights from Mississippi to Des Moines
Explore the most affordable flight options available from Mississippi to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/195:58 pmMEM - DSM
1 stop4h 32mDelta
Sat 5/2412:00 pmDSM - MEM
1 stop5h 01mDelta
Deal found 4/17$242
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/185:15 pmMOB - DSM
1 stop5h 07mDelta
Wed 7/236:30 pmDSM - MOB
1 stop4h 26mDelta
Deal found 4/17$244
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/67:42 amMEM - DSM
1 stop6h 29mAmerican Airlines
Sun 8/105:26 amDSM - MEM
1 stop4h 27mAmerican Airlines
Deal found 4/17$279
This Mytrip deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/18:29 pmMEM - DSM
1 stop25h 52mAllegiant Air
Mon 5/56:00 amDSM - MEM
1 stop13h 34mAllegiant Air
Deal found 4/16$284
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/192:33 pmMEM - DSM
1 stop6h 51mMultiple Airlines
Sat 5/2410:00 amDSM - MEM
2 stops26h 09mMultiple Airlines
Deal found 4/17$291
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/192:45 pmMEM - DSM
2 stops8h 20mSouthwest
Sat 5/248:30 amDSM - MEM
2 stops10h 35mSouthwest
Deal found 4/17$326
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/234:32 pmBTR - DSM
1 stop7h 26mAmerican Airlines
Mon 5/265:27 pmDSM - BTR
1 stop5h 19mAmerican Airlines
Deal found 4/16$359
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/184:35 pmMOB - DSM
2 stops7h 06mAmerican Airlines
Wed 7/235:00 amDSM - MOB
2 stops7h 12mAmerican Airlines
Deal found 4/17$528
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/165:08 pmMEM - DSM
1 stop5h 37mUnited Airlines
Wed 4/2311:38 amDSM - MEM
2 stops10h 37mUnited Airlines
Deal found 4/16$536
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/166:00 amGTR - DSM
1 stop7h 23mDelta
Sun 7/202:14 pmDSM - GTR
1 stop6h 52mDelta
Deal found 4/17$551
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/236:58 pmBTR - DSM
2 stops21h 20mUnited Airlines
Mon 5/266:00 amDSM - BTR
2 stops29h 24mUnited Airlines
Deal found 4/16$643
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1511:30 amMOB - DSM
2 stops23h 06mUnited Airlines
Sun 5/185:45 amDSM - MOB
2 stops30h 18mUnited Airlines
Deal found 4/17$791

Cheapflights Fare Finder

Customize your flight search to find flights from Mississippi to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from Mississippi to Des Moines that are best for you.

Fly from

Mississippi

Fly to

Des Moines

Route

Depart

Return

Price

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Mon 5/19

5:58 pm-10:30 pm

1 stop4h 32m

Des Moines

Sat 5/24

12:00 pm-5:01 pm

1 stop5h 01m

$242

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Fri 7/18

5:15 pm-10:22 pm

1 stop5h 07m

Des Moines

Wed 7/23

6:30 pm-10:56 pm

1 stop4h 26m

$244

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 8/6

7:42 am-2:11 pm

1 stop6h 29m

Des Moines

Sun 8/10

5:26 am-9:53 am

1 stop4h 27m

$279

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Thu 5/1

8:29 pm-10:21 pm

1 stop25h 52m

Des Moines

Mon 5/5

6:00 am-7:34 pm

1 stop13h 34m

$284

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Mon 5/19

2:33 pm-9:24 pm

1 stop6h 51m

Des Moines

Sat 5/24

10:00 am-12:09 pm

2 stops26h 09m

$291

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Mon 5/19

2:45 pm-11:05 pm

2 stops8h 20m

Des Moines

Sat 5/24

8:30 am-7:05 pm

2 stops10h 35m

$326

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Fri 5/23

4:32 pm-11:58 pm

1 stop7h 26m

Des Moines

Mon 5/26

5:27 pm-10:46 pm

1 stop5h 19m

$359

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Fri 7/18

4:35 pm-11:41 pm

2 stops7h 06m

Des Moines

Wed 7/23

5:00 am-12:12 pm

2 stops7h 12m

$528

ColumbusDes Moines

GTR - DSM

GTRDSM

Columbus Golden Triangle Reg.

Wed 7/16

6:00 am-1:23 pm

1 stop7h 23m

Des Moines

Sun 7/20

2:14 pm-9:06 pm

1 stop6h 52m

$551

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Fri 5/23

6:58 pm-4:18 pm

2 stops21h 20m

Des Moines

Mon 5/26

6:00 am-11:24 am

2 stops29h 24m

$643

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Showing 1-10 of 14 results
1
2

Best time to book a flight from Mississippi to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Des Moines

What is the cheapest time of day to fly from MS to DSM?

Find hourly flight availability from Mississippi to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to Des Moines as you normally would.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 17, 2025.
Get a feel of what it's like to fly with Southwest, Delta and United Airlines from Mississippi to Des Moines by reading reviews from past customers. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,280 reviews

Overall

8.0

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.0
Very good
4,280 reviews
Southwest
8.0
Very good
4,280 reviews

Overall

8.0

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,916 reviews
Southwest
8.0
Very good
4,280 reviews

Overall

8.0

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,667 reviews
Southwest
8.0
Very good
4,280 reviews

Overall

8.0

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Allegiant Air
7.3
Good
734 reviews
Southwest
8.0
Very good
4,280 reviews

Overall

8.0

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,280 reviews

Overall

8.0

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mississippi?

    Des Moines (DSM) is the airport you will fly into if you book a flight from Mississippi to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • What are the most popular routes from Mississippi to Des Moines?

    The most popular flight routes from Mississippi to Des Moines are Memphis - Des Moines, Baton Rouge Ryan - Des Moines and Mobile - Des Moines.

  • Can I find deals for flights from Mississippi to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mississippi to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Des Moines.

  • Can I find deals for business class flights from Mississippi to Des Moines?

    Yes. Cheapflights offers flight deals from Mississippi to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Mississippi to Des Moines (average of $336). Flying from Mississippi to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Mississippi?

Book flights to Mississippi if you plan to visit one of these locations
Ames
Altoona
Johnston
Boone
West Des Moines
Ankeny

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Alternative routes for Mississippi to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Mississippi to Des Moines

Discover the top 2 airlines that operate flights from Mississippi to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$205Average$340FlexibilityNo cancel feeOn-time71%
DeltaCheapest$256Average$412FlexibilityNo cancel feeOn-timeN/A

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