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$254+ Cheap flights from Greenville to Des Moines (GSP - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — DSM
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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Cheap flight deals from Greenville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 17, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$284
(Delta)

One-way from

$254
(United Airlines)

Popular in

April

Cheapest in

March

Average price

$557
Provider with most accurate pricing for Greenville-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Greenville-Des Moines flights.
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From Greenville to Des Moines
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One-way flight from Greenville to Des Moines
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Highest demand for flights based on searches. 4% potential increase in price ($19 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Greenville to Des Moines

Cheapest flights from Greenville to Des Moines
Explore the most affordable flight options available from Greenville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/77:35 amGSP - DSM
1 stop4h 06mDelta
Wed 6/113:41 pmDSM - GSP
1 stop7h 14mDelta
Deal found 4/16$284
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/75:18 pmGSP - DSM
1 stop6h 14mUnited Airlines
Wed 6/1111:16 amDSM - GSP
2 stops11h 30mUnited Airlines
Deal found 4/16$289
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/76:39 pmGSP - DSM
1 stop3h 57mAmerican Airlines
Wed 8/139:35 amDSM - GSP
1 stop5h 05mAmerican Airlines
Deal found 4/17$300
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1510:34 amGSP - DSM
2 stops35h 21mMultiple Airlines
Sun 5/181:44 pmDSM - GSP
1 stop23h 32mMultiple Airlines
Deal found 4/17$345
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/77:20 amGSP - DSM
2 stops9h 10mSouthwest
Wed 6/115:25 amDSM - GSP
2 stops12h 00mSouthwest
Deal found 4/16$415

Cheapflights Fare Finder

Customize your flight search to find flights from Greenville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from Greenville to Des Moines that are best for you.

Fly from

Greenville

Fly to

Des Moines

Route

Depart

Return

Price

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 6/7

7:35 am-10:41 am

1 stop4h 06m

Des Moines

Wed 6/11

3:41 pm-11:55 pm

1 stop7h 14m

$284

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 6/7

5:18 pm-10:32 pm

1 stop6h 14m

Des Moines

Wed 6/11

11:16 am-11:46 pm

2 stops11h 30m

$289

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 6/7

6:15 pm-11:52 pm

2 stops6h 37m

Des Moines

Sun 6/22

5:00 am-10:53 am

1 stop4h 53m

$337

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 5/15

10:34 am-8:55 pm

2 stops35h 21m

Des Moines

Sun 5/18

1:44 pm-2:16 pm

1 stop23h 32m

$345

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 6/7

7:20 am-3:30 pm

2 stops9h 10m

Des Moines

Wed 6/11

5:25 am-6:25 pm

2 stops12h 00m

$415

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 4/30

6:50 am-10:40 am

1 stop4h 50m

$254

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Compare providers for flights from Greenville to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Des Moines in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Des Moines

What is the cheapest month to book a flight from Greenville to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $336). Flying from Greenville to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to DSM?

Find hourly flight availability from Greenville to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

It’s typically best to fly out from Greenville to Des Moines at noon. Doing so could potentially save you 39% on the flight price compared to flying in the evening, which is usually more expensive.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 17, 2025.
Southwest
8.0
Very good
4,280 reviews

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Overall

8.0

Crew

8.6

Food

7.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.0
Very good
4,280 reviews
Southwest
8.0
Very good
4,280 reviews

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Overall

8.0

Crew

8.6

Food

7.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,917 reviews
Southwest
8.0
Very good
4,280 reviews

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Overall

8.0

Crew

8.6

Food

7.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,667 reviews
Southwest
8.0
Very good
4,280 reviews

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Overall

8.0

Crew

8.6

Food

7.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,280 reviews

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Overall

8.0

Crew

8.6

Food

7.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Greenville to Des Moines round-trip?

    Currently priced at $284, Delta will fly you from Greenville to Des Moines and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from United Airlines and American Airlines - these airlines can fly you to your destination from $289 and $337, respectively. These flights start at 30% lower than the current average price 3 months from now.

  • Can I find deals for flights from Greenville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Greenville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Des Moines.

  • Can I find deals for business class flights from Greenville to Des Moines?

    Yes. Cheapflights offers flight deals from Greenville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $336). Flying from Greenville to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Ames
Altoona
Johnston
Boone
West Des Moines
Ankeny

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Top 2 airlines flying from Greenville to Des Moines

Discover the top 2 airlines that operate flights from Greenville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$294Average$366FlexibilityNo cancel feeOn-time71%
DeltaCheapest$296Average$396FlexibilityNo cancel feeOn-timeN/A

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