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$162+ Cheap flights from Knoxville to Charleston (TYS - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/31. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Jan 13 — Jan 201
Tue 1/13
Tue 1/20
1 adult, Economy
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Cheap flight deals from Knoxville to Charleston

Cheapest flights from Knoxville to Charleston
Explore the most affordable flight options available from Knoxville to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 14, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:38 pmTYS - CHS
1 stop14h 59mMultiple Airlines
Thu 12/252:59 pmCHS - TYS
1 stop19h 16mMultiple Airlines
Deal found 12/13$305
This Mytrip deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/269:23 amTYS - CHS
1 stop12h 00mMultiple Airlines
Mon 12/2910:18 pmCHS - TYS
1 stop10h 00mMultiple Airlines
Deal found 12/12$434
This Mytrip deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/269:23 amTYS - CHS
1 stop12h 00mMultiple Airlines
Sun 12/2810:18 pmCHS - TYS
2 stops21h 35mMultiple Airlines
Deal found 12/12$448
This Kiwi.com deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:38 pmTYS - CHS
1 stop14h 59mMultiple Airlines
Sat 12/275:20 pmCHS - TYS
2 stops40h 55mMultiple Airlines
Deal found 12/12$463
This Kiwi.com deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/164:52 pmTYS - CHS
2 stops44h 18mMultiple Airlines
Thu 12/1810:18 pmCHS - TYS
1 stop17h 16mMultiple Airlines
Deal found 12/12$483
This Kiwi.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:23 pmTYS - CHS
1 stop24h 00mMultiple Airlines
Sat 12/275:20 pmCHS - TYS
2 stops40h 55mMultiple Airlines
Deal found 12/13$485
This Delta deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:59 pmTYS - CHS
1 stop4h 59mDelta
Sat 12/278:05 pmCHS - TYS
1 stop3h 24mDelta
Deal found 12/13$486
This Kiwi.com deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/279:17 pmTYS - CHS
1 stop24h 06mMultiple Airlines
Wed 12/316:25 amCHS - TYS
2 stops14h 42mMultiple Airlines
Deal found 12/12$511
This Delta deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:35 amTYS - CHS
1 stop5h 21mDelta
Sat 12/274:04 pmCHS - TYS
1 stop3h 23mDelta
Deal found 12/12$523

Find flight deals from Knoxville to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 14, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$265
(Kiwi.com)

One-way from

$162
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$813
Provider with most accurate pricing for Knoxville McGhee Tyson-Charleston flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Charleston flights.
Search Deals
From Knoxville McGhee Tyson to Charleston
Search Deals
One-way flight from Knoxville McGhee Tyson to Charleston
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($121 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($32 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 14, 2025.
Use the filters below to find and compare flights from Knoxville to Charleston that are best for you.

Fly from

Knoxville

Fly to

Charleston

Route

Depart

Return

Price

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 12/22

5:38 pm-8:37 am

1 stop14h 59m

Charleston

Thu 12/25

2:59 pm-10:15 am

1 stop19h 16m

$305

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 1/22

11:58 am-4:06 pm

1 stop4h 08m

Charleston

Thu 1/29

5:25 am-9:21 am

1 stop3h 56m

$327

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 2/12

5:30 am-9:23 am

1 stop3h 53m

Charleston

Fri 2/13

7:00 pm-9:04 am

1 stop14h 04m

$357

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 2/11

10:58 am-8:38 am

2 stops21h 40m

Charleston

Fri 2/13

1:39 pm-11:38 pm

1 stop9h 59m

$394

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 2/12

7:00 am-9:59 pm

2 stops14h 59m

Charleston

Fri 2/13

1:39 pm-11:38 pm

1 stop9h 59m

$432

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 12/26

9:23 am-9:23 pm

1 stop12h 00m

Charleston

Mon 12/29

10:18 pm-5:59 pm

2 stops19h 41m

$441

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 12/26

9:23 am-9:23 pm

1 stop12h 00m

Charleston

Sun 12/28

10:18 pm-7:53 pm

2 stops21h 35m

$448

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 12/22

5:38 pm-8:37 am

1 stop14h 59m

Charleston

Sat 12/27

5:20 pm-10:15 am

2 stops40h 55m

$463

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 1/23

7:20 pm-7:11 pm

1 stop23h 51m

Charleston

Mon 1/26

7:45 pm-2:49 pm

1 stop19h 04m

$469

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 12/22

5:40 pm-12:05 am

1 stop6h 25m

Charleston

Sun 12/28

5:10 am-8:56 am

1 stop3h 46m

$483

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 17 results
1
2

Compare providers for flights from Knoxville to Charleston

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Charleston in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Charleston flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Charleston flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Charleston flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Charleston flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Charleston

What is the cheapest month to book a flight from Knoxville to Charleston?

Currently, June is the cheapest month in which you can book a flight from Knoxville to Charleston (average of $174). Flying from Knoxville to Charleston in December is currently the most expensive (average of $319). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CHS?

Find hourly flight availability from Knoxville to Charleston. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 14, 2025.

When flying from Knoxville to Charleston, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 18% versus a flight in the afternoon.

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated December 14, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Charleston to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Overall

7.9

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Overall

7.9

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,007 reviews

Overall

7.9

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Charleston?

    A quick flight from Knoxville to Charleston can take about 4h 08m. Delta provides one of the quickest options available for as low as $327. The distance between Knoxville and Charleston is about 302 mi.

  • What are the cheapest airlines flying from Knoxville to Charleston round-trip?

    Currently priced at $296, American Airlines will fly you from Knoxville to Charleston and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $316. You may be able to fly from Knoxville to Charleston for 35% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Charleston that include hotel bookings?

    Yes. In addition to deals on Knoxville to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Charleston.

  • Can I find deals for business class flights from Knoxville to Charleston?

    Yes. Cheapflights offers flight deals from Knoxville to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Charleston?

    Currently, June is the cheapest month in which you can book a flight from Knoxville to Charleston (average of $174). Flying from Knoxville to Charleston in December is currently the most expensive (average of $319). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Edisto Beach

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Top 2 airlines flying from Knoxville to Charleston

Discover the top 2 airlines that operate flights from Knoxville to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$296Average$424FlexibilityNo cancel feeOn-time71%
DeltaCheapest$316Average$412FlexibilityNo cancel feeOn-timeN/A

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