What are the cheapest airlines flying from Des Moines to Charleston round-trip?

Flying on United Airlines is currently your cheapest option to Charleston, with prices starting at $271. Additional round-trip tickets that might be worth considering are offered by Southwest and American Airlines, with the lowest prices starting at $276 and $284, respectively. United Airlines is currently priced 32% below the average price you’ll pay for this route.

What are the cheapest airlines to fly from Des Moines to Charleston one-way?

The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $136. However, be on the lookout for offers from Delta and United Airlines, as they are both options that can get you from Des Moines to Charleston for a low price.

What is the cheapest day to fly from Des Moines to Charleston?

Travelers seeking maximum savings on their Des Moines to Charleston flight should consider departing on Friday at noon when fares are most often at their lowest. Wednesday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from Des Moines to Charleston?

American Airlines, Delta and United Airlines are the most popular airlines when flying from Des Moines to Charleston.

What is the cheapest day to fly round-trip from Des Moines to Charleston?

Users have found that leaving on a Sunday can be a cost-effective option. It’s possible to save up to 34% on your flight compared to booking on days when demand is much higher.

How far in advance should I book a flight from Des Moines to Charleston?

Travelers have found it’s best to book a flight 59 days in advance to save up to 110% compared to booking the same week of travel. As your travel date approaches, the cost of this flight route may potentially increase. While opting to book 59 days out may not be an option for all, there are still additional ways to secure a deal in the near future. You might find a flight from Des Moines to Charleston 1-2 weeks in advance for as low as $484, or $594 for flights within the next 24 hours.

What is the cheapest month to fly from Des Moines to Charleston?

Flights from Des Moines to Charleston lean towards being more expensive in March. Prices are generally better when you fly from Des Moines to Charleston in September, with the cheapest ticket starting at $254.

What is the cheapest time of day to fly from DSM to CHS?

A simple way to save on the total cost of your ticket is to fly from Des Moines to Charleston in the afternoon. If you’re flexible enough to do this you can expect to save up to 5% on your trip compared to booking a flight in the morning.

Most accurate provider : When it comes to deals on Des Moines-Charleston flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Des Moines-Charleston flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Des Moines-Charleston flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-Charleston flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to Charleston that include hotel bookings?

Yes. In addition to deals on Des Moines to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Charleston?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Charleston.

Can I find deals for business class flights from Des Moines to Charleston?

Yes. Cheapflights offers flight deals from Des Moines to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$136+ Flights from Des Moines to Charleston

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

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3. Compare prices and book

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Cheapflights Tip: The best prices from Des Moines to Charleston are usually found in September or August, booked 64 days in advance, depart on a Monday or Friday and return on a Wednesday

Cheap flight deals from Des Moines to Charleston

Most accurate provider	Mytrip 3 stars
Most trusted provider	Mytrip 3 stars
Round-trip from	$218 (Mytrip)
One-way from	$136 (American Airlines)
Popular in	March
Cheapest in	September
Average price	$364

Provider with most accurate pricing for Des Moines-Charleston flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-Charleston flights.

Search Deals

From Des Moines to Charleston

Search Deals

One-way flight from Des Moines to Charleston

Search Deals

Highest demand for flights based on searches. 10% potential increase in price ($46 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($16 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in April 2025

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Find flight deals from Des Moines to Charleston

Cheapest flights from Des Moines to Charleston
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2025.

Fri 5/22:28 pmDSM - CHS

1 stop18h 44mMultiple Airlines

Mon 5/510:32 amCHS - DSM

1 stop12h 26mMultiple Airlines

Deal found 4/15

$218

Tue 5/63:34 pmDSM - CHS

1 stop5h 25mUnited Airlines

Sat 5/104:30 pmCHS - DSM

1 stop6h 22mUnited Airlines

Deal found 4/15

$271

Tue 5/66:40 amDSM - CHS

2 stops10h 40mSouthwest

Sat 5/1010:45 amCHS - DSM

1 stop6h 05mSouthwest

Deal found 4/15

$276

Wed 5/71:12 pmDSM - CHS

1 stop8h 38mAmerican Airlines

Sat 5/176:10 pmCHS - DSM

1 stop6h 48mAmerican Airlines

Deal found 4/15

$284

Wed 5/77:01 amDSM - CHS

1 stop6h 15mDelta

Sat 5/176:37 amCHS - DSM

2 stops6h 50mDelta

Deal found 4/15

$289

Best flights from Des Moines to Charleston
Discover carefully curated flight deals from Des Moines to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 15, 2025.

Fri 5/22:28 pmDSM - CHS

1 stop18h 44mMultiple Airlines

Mon 5/510:32 amCHS - DSM

1 stop12h 26mMultiple Airlines

Deal found 4/15

$218

Tue 5/63:34 pmDSM - CHS

1 stop5h 25mUnited Airlines

Sat 5/104:30 pmCHS - DSM

1 stop6h 22mUnited Airlines

Deal found 4/15

$271

Tue 5/66:40 amDSM - CHS

2 stops10h 40mSouthwest

Sat 5/1010:45 amCHS - DSM

1 stop6h 05mSouthwest

Deal found 4/15

$276

Wed 5/71:12 pmDSM - CHS

1 stop8h 38mAmerican Airlines

Sat 5/176:10 pmCHS - DSM

1 stop6h 48mAmerican Airlines

Deal found 4/15

$284

Wed 5/77:01 amDSM - CHS

1 stop6h 15mDelta

Sat 5/176:37 amCHS - DSM

2 stops6h 50mDelta

Deal found 4/15

$289

Last-minute flights from Des Moines to Charleston
Discover last-minute flight deals from Des Moines to Charleston. Data last updated April 15, 2025 and is based on user searches.

Wed 4/232:12 pmDSM - CHS

2 stops8h 45mAmerican Airlines

Tue 4/292:20 pmCHS - DSM

1 stop8h 29mAmerican Airlines

Deal found 4/15

$482

Wed 4/2311:38 amDSM - CHS

3 stops11h 21mUnited Airlines

Tue 4/296:00 amCHS - DSM

2 stops9h 38mUnited Airlines

Deal found 4/15

$892

Fri 5/22:28 pmDSM - CHS

1 stop18h 44mMultiple Airlines

Mon 5/510:32 amCHS - DSM

1 stop12h 26mMultiple Airlines

Deal found 4/15

$218

Tue 5/63:34 pmDSM - CHS

1 stop5h 25mUnited Airlines

Sat 5/104:30 pmCHS - DSM

1 stop6h 22mUnited Airlines

Deal found 4/15

$271

Tue 5/66:40 amDSM - CHS

2 stops10h 40mSouthwest

Sat 5/1010:45 amCHS - DSM

1 stop6h 05mSouthwest

Deal found 4/15

$276

Wed 5/71:12 pmDSM - CHS

1 stop8h 38mAmerican Airlines

Sat 5/176:10 pmCHS - DSM

1 stop6h 48mAmerican Airlines

Deal found 4/15

$284

Wed 5/77:01 amDSM - CHS

1 stop6h 15mDelta

Sat 5/176:37 amCHS - DSM

2 stops6h 50mDelta

Deal found 4/15

$289

One-way flights from Des Moines to Charleston
Search for one-way flight options from Des Moines to Charleston. Find affordable one-way fares based on user searches. Data last updated April 15, 2025.

Wed 5/286:45 amDSM - CHS

1 stop6h 35mAmerican Airlines

Deal found 4/15

$136

Fri 5/161:07 pmDSM - CHS

2 stops9h 37mDelta

Deal found 4/15

$199

Wed 5/2811:16 amDSM - CHS

3 stops11h 43mUnited Airlines

Deal found 4/15

$508

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 5/2

2:28 pm-10:12 am

1 stop18h 44m

Charleston

Mon 5/5

10:32 am-9:58 pm

1 stop12h 26m

$218

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 5/6

3:34 pm-9:59 pm

1 stop5h 25m

Charleston

Sat 5/10

4:30 pm-9:52 pm

1 stop6h 22m

$271

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 5/6

6:40 am-6:20 pm

2 stops10h 40m

Charleston

Sat 5/10

10:45 am-3:50 pm

1 stop6h 05m

$276

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 5/7

1:12 pm-10:50 pm

1 stop8h 38m

Charleston

Sat 5/17

6:10 pm-11:58 pm

1 stop6h 48m

$284

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 5/7

7:01 am-2:16 pm

1 stop6h 15m

Charleston

Sat 5/17

6:37 am-12:27 pm

2 stops6h 50m

$289

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 5/28

6:45 am-2:20 pm

1 stop6h 35m

$136

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 5/16

1:07 pm-11:44 pm

2 stops9h 37m

$199

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 5/28

11:16 am-11:59 pm

3 stops11h 43m

$508

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/15

Compare providers for flights from Des Moines to Charleston

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Charleston in April.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*2 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Mytrip	Price Accuracy3 stars	Trust Score*3 stars
Priceline	Price Accuracy1 star	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-Charleston flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Des Moines-Charleston flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Des Moines-Charleston flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-Charleston flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Charleston

How far ahead should I book a flight from Des Moines to Charleston?

The price you pay for your flight from Des Moines to Charleston may vary depending on when you book. For the best chance of a lower fare, look to book 64 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Charleston?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $217). Flying from Des Moines to Charleston in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Charleston by month

In terms of precipitation, rainfall in Charleston ranges from 2.4 - 7.2 inches per month. August is typically the wettest month, when rainfall can reach 7.2 in. November is typically the driest time to visit Charleston when rainfall is around 2.4 in.

Temperature in Charleston by month

If weather is an important factor for your trip to Charleston, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 82.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 48.2 F).

Reviews of airlines servicing Charleston

Peruse reviews from past customers who have flown with Southwest, Delta and United Airlines from Des Moines to Charleston to help guide your decision. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,279 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Southwest

8.0

Very good

4,279 reviews

Southwest

8.0

Very good

4,279 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Delta

8.0

Very good

7,917 reviews

Southwest

8.0

Very good

4,279 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

United Airlines

7.4

Good

8,658 reviews

Southwest

8.0

Very good

4,279 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,279 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

What are the cheapest airlines flying from Des Moines to Charleston round-trip?
Flying on United Airlines is currently your cheapest option to Charleston, with prices starting at $271. Additional round-trip tickets that might be worth considering are offered by Southwest and American Airlines, with the lowest prices starting at $276 and $284, respectively. United Airlines is currently priced 32% below the average price you’ll pay for this route.
What are the cheapest airlines to fly from Des Moines to Charleston one-way?
The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $136. However, be on the lookout for offers from Delta and United Airlines, as they are both options that can get you from Des Moines to Charleston for a low price.
Can I find deals for flights from Des Moines to Charleston that include hotel bookings?
Yes. In addition to deals on Des Moines to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Charleston?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Charleston.
Can I find deals for business class flights from Des Moines to Charleston?
Yes. Cheapflights offers flight deals from Des Moines to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Charleston?
Currently, August is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $217). Flying from Des Moines to Charleston in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Des Moines to Charleston

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$249	Average$407	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$261	Average$381	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$311	Average$553	FlexibilityNo cancel fee	On-time69%

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$136+ Cheap flights from Des Moines to Charleston (DSM - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/28. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Charleston with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Des Moines to Charleston are usually found in September or August, booked 64 days in advance, depart on a Monday or Friday and return on a Wednesday

Cheap flight deals from Des Moines to Charleston

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to Charleston

Cheapest flights from Des Moines to CharlestonExplore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2025.

Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Compare providers for flights from Des Moines to Charleston

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Charleston in April.

Best time to book a flight from Des Moines to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Charleston

How far ahead should I book a flight from Des Moines to Charleston?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Charleston. Price data was last updated on April 11, 2025.

What is the cheapest month to book a flight from Des Moines to Charleston?

Rainfall in Charleston by month

Plan your trip to Charleston by taking into account the average rainfall totals by month.

Temperature in Charleston by month

Plan your trip to Charleston by taking into account the average temperature totals by month.

Reviews of airlines servicing Charleston

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Des Moines to Charleston round-trip?

What are the cheapest airlines to fly from Des Moines to Charleston one-way?

Can I find deals for flights from Des Moines to Charleston that include hotel bookings?

How can I find direct flights from Des Moines to Charleston?

Can I find deals for business class flights from Des Moines to Charleston?

What is the cheapest month to book a flight from Des Moines to Charleston?

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Top 3 airlines flying from Des Moines to Charleston

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Cheapest flights from Des Moines to Charleston
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2025.