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Central America

$183+ Cheap flights from Knoxville (TYS) to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/24. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SJO
Apr 9 — Apr 161
Wed 4/9
Wed 4/16
1 adult, Economy
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Cheap flight deals from Knoxville to Central America

Keep the following information in mind while searching for Knoxville to Central America flight deals. Data was last updated April 4, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$336
(Mytrip)

One-way from

$183
(Mytrip)

Popular in

December

Cheapest in

April

Average price

$457
Provider with most accurate pricing for Knoxville McGhee Tyson-San Salvador El Salvador Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Salvador El Salvador Intl flights.
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From Knoxville McGhee Tyson to Central America
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One-way flight from Knoxville McGhee Tyson to Central America
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Highest demand for flights based on searches. 16% potential increase in price ($130 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($48 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Knoxville to Central America

Cheapest flights from Knoxville to Central America
Explore the most affordable flight options available from Knoxville to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2025.

This Mytrip deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/243:52 pmTYS - GUA
1 stop10h 12mMultiple Airlines
Sat 5/312:36 pmGUA - TYS
1 stop28h 10mMultiple Airlines
Deal found 4/4$336
This Mytrip deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/198:00 amTYS - SJO
1 stop28h 27mMultiple Airlines
Mon 5/2611:32 amSJO - TYS
2 stops26h 40mMultiple Airlines
Deal found 4/3$383
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/242:26 pmTYS - PTY
2 stops24h 49mAmerican Airlines
Fri 8/293:16 pmPTY - TYS
2 stops18h 04mAmerican Airlines
Deal found 4/4$440
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/135:45 amTYS - LIR
1 stop8h 15mDelta
Thu 5/221:25 pmLIR - TYS
1 stop8h 26mDelta
Deal found 4/4$449
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/137:44 pmTYS - LIR
2 stops17h 36mAmerican Airlines
Thu 5/2212:45 pmLIR - TYS
2 stops17h 39mAmerican Airlines
Deal found 4/3$453
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/249:15 amTYS - PTY
1 stop30h 04mUnited Airlines
Fri 8/293:20 pmPTY - TYS
1 stop25h 17mUnited Airlines
Deal found 4/4$453
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/77:13 amTYS - SJO
1 stop6h 07mAmerican Airlines
Fri 9/192:20 pmSJO - TYS
1 stop7h 05mAmerican Airlines
Deal found 4/4$454
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/17:54 pmTYS - BZE
2 stops17h 26mAmerican Airlines
Fri 6/611:15 amBZE - TYS
1 stop11h 09mAmerican Airlines
Deal found 4/3$458
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/186:55 amTYS - SAL
1 stop7h 05mAmerican Airlines
Sat 5/31:11 pmSAL - TYS
1 stop8h 18mAmerican Airlines
Deal found 4/4$463
This Delta deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/65:30 amTYS - BZE
1 stop7h 41mDelta
Tue 5/131:03 pmBZE - TYS
1 stop8h 48mDelta
Deal found 4/3$474
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/156:55 amTYS - GUA
1 stop13h 35mAmerican Airlines
Tue 4/292:45 pmGUA - TYS
1 stop6h 44mAmerican Airlines
Deal found 4/4$488
This Mytrip deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/181:29 pmTYS - SAL
2 stops36h 16mMultiple Airlines
Sat 5/39:10 amSAL - TYS
2 stops33h 45mMultiple Airlines
Deal found 4/4$501

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2025.
Use the filters below to find and compare flights from Knoxville to Central America that are best for you.

Fly from

Knoxville

Fly to

Central America

Route

Depart

Return

Price

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Thu 4/24

3:52 pm-12:04 am

1 stop10h 12m

Guatemala City La Aurora

Sat 5/3

12:36 pm-6:46 pm

1 stop28h 10m

$336

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Mon 5/19

8:00 am-10:27 am

1 stop28h 27m

San José Juan Santamaria Intl

Mon 5/26

11:32 am-4:12 pm

2 stops26h 40m

$383

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 8/24

2:26 pm-2:15 pm

2 stops24h 49m

Panama City Tocumen Intl

Fri 8/29

3:16 pm-10:20 am

2 stops18h 04m

$440

KnoxvilleLiberia

TYS - LIR

TYSLIR

Knoxville McGhee Tyson

Tue 5/13

5:45 am-12:00 pm

1 stop8h 15m

Liberia

Thu 5/22

1:25 pm-11:51 pm

1 stop8h 26m

$449

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 8/24

9:15 am-2:19 pm

1 stop30h 04m

Panama City Tocumen Intl

Fri 8/29

3:20 pm-5:37 pm

1 stop25h 17m

$453

KnoxvilleLiberia

TYS - LIR

TYSLIR

Knoxville McGhee Tyson

Tue 5/13

7:44 pm-11:20 am

2 stops17h 36m

Liberia

Thu 5/22

12:45 pm-8:24 am

2 stops17h 39m

$453

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Sun 9/7

7:13 am-11:20 am

1 stop6h 07m

San José Juan Santamaria Intl

Fri 9/19

2:20 pm-11:25 pm

1 stop7h 05m

$454

KnoxvilleBelize City

TYS - BZE

TYSBZE

Knoxville McGhee Tyson

Sun 6/1

7:54 pm-11:20 am

2 stops17h 26m

Belize City Philip S.W.Goldson

Fri 6/6

11:15 am-12:24 am

1 stop11h 09m

$458

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

Fri 4/18

6:55 am-12:00 pm

1 stop7h 05m

San Salvador El Salvador Intl

Sat 5/3

1:11 pm-11:29 pm

1 stop8h 18m

$463

KnoxvilleBelize City

TYS - BZE

TYSBZE

Knoxville McGhee Tyson

Tue 5/6

5:30 am-11:11 am

1 stop7h 41m

Belize City Philip S.W.Goldson

Tue 5/13

1:03 pm-11:51 pm

1 stop8h 48m

$474

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/3

Showing 1-10 of 29 results
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Best time to book a flight from Knoxville to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Central America

What is the cheapest month to book a flight from Knoxville to Central America?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Central America (average of $398). Flying from Knoxville to Central America in March is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CA?

Find hourly flight availability from Knoxville to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 4, 2025.

When flying from Knoxville to Central America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Central America by month

Plan your trip to Central America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Central America ranges from 0.0 - 13.0 inches per month. August is typically the wettest month, when rainfall can reach 13.0 in. February is typically the driest time to visit Central America when rainfall is around 0.0 in.

Temperature in Central America by month

Plan your trip to Central America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Central America, use this chart to help with planning. For those seeking warmer temperatures, March is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 73.4 F).

Reviews of airlines servicing Central America

Get insights into the airlines that provide service to Central America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Central America. Reviews last updated April 4, 2025.
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Food

7.3

Overall

8.0

Comfort

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,899 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Food

7.3

Overall

8.0

Comfort

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,404 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Food

7.3

Overall

8.0

Comfort

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,618 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Food

7.3

Overall

8.0

Comfort

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Food

7.3

Overall

8.0

Comfort

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Air Canada
7.0
Good
9,040 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Food

7.3

Overall

8.0

Comfort

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Central America?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Central America. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • What are the most popular routes from Knoxville to Central America?

    While some choose either Knoxville McGhee Tyson - San José Juan Santamaria Intl or Knoxville McGhee Tyson - Belize City Philip S.W.Goldson, Knoxville McGhee Tyson - Liberia is the most popular route from Knoxville to Central America.

  • Can I find deals for flights from Knoxville to Central America that include hotel bookings?

    Yes. In addition to deals on Knoxville to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Central America.

  • Can I find deals for business class flights from Knoxville to Central America?

    Yes. Cheapflights offers flight deals from Knoxville to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Central America?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Central America (average of $398). Flying from Knoxville to Central America in March is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Central America

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Top 3 airlines flying from Knoxville to Central America

Discover the top 3 airlines that operate flights from Knoxville to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$387Average$734FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$388Average$663FlexibilityNo cancel feeOn-time71%
DeltaCheapest$390Average$578FlexibilityNo cancel feeOn-timeN/A

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