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Central America

$126+ Cheap flights from Knoxville (TYS) to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SJO
Mar 8 — Mar 151
Sat 3/8
Sat 3/15
1 adult, Economy
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Cheap flight deals from Knoxville to Central America

Keep the following information in mind while searching for Knoxville to Central America flight deals. Data was last updated March 3, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$323
(Kiwi.com)

One-way from

$126
(Mytrip)

Popular in

December

Cheapest in

April

Average price

$511
Provider with most accurate pricing for Knoxville McGhee Tyson-San Salvador El Salvador Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Salvador El Salvador Intl flights.
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From Knoxville McGhee Tyson to Central America
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One-way flight from Knoxville McGhee Tyson to Central America
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Highest demand for flights based on searches. 19% potential increase in price ($161 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($45 potential savings vs. average RT price).
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Average for round-trip flights in March 2025
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Find flight deals from Knoxville to Central America

Cheapest flights from Knoxville to Central America
Explore the most affordable flight options available from Knoxville to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 3, 2025.

This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2810:03 pmTYS - SJO
1 stop14h 22mMultiple Airlines
Thu 4/312:50 amSJO - TYS
1 stop18h 25mMultiple Airlines
Deal found 3/2$323
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/55:15 pmTYS - GUA
1 stop8h 49mMultiple Airlines
Sat 5/2412:26 pmGUA - TYS
1 stop29h 19mMultiple Airlines
Deal found 3/2$343
This United Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/317:00 amTYS - PTY
1 stop12h 37mUnited Airlines
Mon 4/73:20 pmPTY - TYS
1 stop23h 31mUnited Airlines
Deal found 3/3$413
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/245:15 pmTYS - SAL
1 stop8h 43mUnited Airlines
Sat 5/3111:45 pmSAL - TYS
1 stop8h 42mUnited Airlines
Deal found 3/2$426
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/25:30 pmTYS - PTY
2 stops19h 45mAmerican Airlines
Fri 5/91:20 pmPTY - TYS
2 stops20h 50mAmerican Airlines
Deal found 3/2$428
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/137:55 pmTYS - LIR
1 stop17h 20mAmerican Airlines
Thu 5/222:05 pmLIR - TYS
1 stop7h 53mAmerican Airlines
Deal found 3/3$449
This Delta deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/45:30 amTYS - LIR
1 stop8h 07mDelta
Sun 5/111:25 pmLIR - TYS
1 stop8h 26mDelta
Deal found 3/2$467
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/36:53 amTYS - SAL
1 stop7h 11mAmerican Airlines
Tue 4/151:28 pmSAL - TYS
1 stop8h 27mAmerican Airlines
Deal found 3/3$470
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/17:55 pmTYS - BZE
2 stops17h 25mAmerican Airlines
Fri 6/63:10 pmBZE - TYS
2 stops17h 06mAmerican Airlines
Deal found 3/2$476
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1512:34 pmTYS - SJO
1 stop11h 43mAmerican Airlines
Sun 5/1811:59 pmSJO - TYS
1 stop12h 06mAmerican Airlines
Deal found 3/3$492
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/276:53 amTYS - MGA
1 stop8h 28mAmerican Airlines
Mon 3/316:14 amMGA - TYS
1 stop14h 40mAmerican Airlines
Deal found 3/2$502
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/156:55 amTYS - GUA
1 stop13h 35mAmerican Airlines
Tue 4/2912:40 pmGUA - TYS
1 stop8h 49mAmerican Airlines
Deal found 3/3$522

Find flights from Knoxville to Central America within your budget

Customize your flight search to find flights from Knoxville to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 3, 2025.

Fly from

Knoxville

Fly to

Central America

Route

Depart

Return

Price

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Fri 3/28

10:03 pm-10:25 am

1 stop14h 22m

San José Juan Santamaria Intl

Thu 4/3

12:50 am-9:15 pm

1 stop18h 25m

$323

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Mon 5/5

5:15 pm-12:04 am

1 stop8h 49m

Guatemala City La Aurora

Sat 5/24

12:26 pm-7:45 pm

1 stop29h 19m

$343

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 3/31

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Mon 4/7

3:20 pm-3:51 pm

1 stop23h 31m

$413

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

Sat 5/24

5:15 pm-11:58 pm

1 stop8h 43m

San Salvador El Salvador Intl

Sat 5/31

11:45 pm-10:27 am

1 stop8h 42m

$426

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 5/2

5:30 pm-12:15 pm

2 stops19h 45m

Panama City Tocumen Intl

Fri 5/9

1:20 pm-11:10 am

2 stops20h 50m

$428

KnoxvilleLiberia

TYS - LIR

TYSLIR

Knoxville McGhee Tyson

Tue 5/13

7:55 pm-11:15 am

1 stop17h 20m

Liberia

Thu 5/22

2:05 pm-11:58 pm

1 stop7h 53m

$449

KnoxvilleLiberia

TYS - LIR

TYSLIR

Knoxville McGhee Tyson

Sun 5/4

5:30 am-11:37 am

1 stop8h 07m

Liberia

Sun 5/11

1:25 pm-11:51 pm

1 stop8h 26m

$467

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

Thu 4/3

6:53 am-12:04 pm

1 stop7h 11m

San Salvador El Salvador Intl

Tue 4/15

1:28 pm-11:55 pm

1 stop8h 27m

$470

KnoxvilleBelize City

TYS - BZE

TYSBZE

Knoxville McGhee Tyson

Sun 6/1

7:55 pm-11:20 am

2 stops17h 25m

Belize City Philip S.W.Goldson

Fri 6/6

3:10 pm-12:24 am

1 stop7h 14m

$476

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Thu 5/15

12:34 pm-10:17 pm

1 stop11h 43m

San José Juan Santamaria Intl

Sun 5/18

11:59 pm-2:05 pm

1 stop12h 06m

$492

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/3

Showing 1-10 of 40 results
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Best time to book a flight from Knoxville to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Knoxville to Central America

Get recent, data-driven insights about flights from Knoxville to Central America including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Knoxville to Central America?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Central America (average of $398). Flying from Knoxville to Central America in March is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CA?

Find hourly flight availability from Knoxville to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 3, 2025.

When flying from Knoxville to Central America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Central America by month

Plan your trip to Central America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Central America ranges from 0.0 - 13.0 inches per month. August is typically the wettest month, when rainfall can reach 13.0 in. February is typically the driest time to visit Central America when rainfall is around 0.0 in.

Temperature in Central America by month

Plan your trip to Central America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Central America, use this chart to help with planning. For those seeking warmer temperatures, March is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 73.4 F).

Reviews of airlines servicing Central America

Get insights into the airlines that provide service to Central America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Central America. Reviews last updated March 3, 2025.
Delta
8.0
Very good
8,070 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta
8.0
Very good
8,070 reviews
Delta
8.0
Very good
8,070 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Aeromexico
7.5
Good
1,747 reviews
Delta
8.0
Very good
8,070 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines
7.4
Good
8,679 reviews
Delta
8.0
Very good
8,070 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,070 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

WestJet
7.2
Good
2,788 reviews
Delta
8.0
Very good
8,070 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Central America?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Central America. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • What are the cheapest airlines to fly from Knoxville to Central America one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $248. United Airlines flights start at $304 while deals on Delta start at $310 one-way.

  • What are the most popular routes from Knoxville to Central America?

    While some choose either Knoxville McGhee Tyson - San José Juan Santamaria Intl or Knoxville McGhee Tyson - Belize City Philip S.W.Goldson, Knoxville McGhee Tyson - Liberia is the most popular route from Knoxville to Central America.

  • Can I find deals for flights from Knoxville to Central America that include hotel bookings?

    Yes. In addition to deals on Knoxville to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Central America.

  • Can I find deals for business class flights from Knoxville to Central America?

    Yes. Cheapflights offers flight deals from Knoxville to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Central America?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Central America (average of $398). Flying from Knoxville to Central America in March is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Knoxville to Central America

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Top 3 airlines flying from Knoxville to Central America

Discover the top 3 airlines that operate flights from Knoxville to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$288Average$720FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$388Average$667FlexibilityNo cancel feeOn-time71%
DeltaCheapest$390Average$589FlexibilityNo cancel feeOn-timeN/A
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