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Cayman Islands

$149+ Cheap flights from Missouri to the Cayman Islands

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/28. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Missouri to Cayman Islands

Cheapest flights from Missouri to Cayman Islands
Explore the most affordable flight options available from Missouri to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:30 amSTL - GCM
2 stops9h 00mUnited Airlines
Thu 12/185:45 pmGCM - STL
1 stop17h 04mUnited Airlines
Deal found 12/10$360
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:00 amSTL - GCM
2 stops13h 15mAmerican Airlines
Thu 12/183:45 pmGCM - STL
2 stops17h 50mAmerican Airlines
Deal found 12/10$395
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:15 pmMCI - GCM
1 stop18h 30mSpirit Airlines
Sun 1/42:40 pmGCM - MCI
1 stop27h 30mSpirit Airlines
Deal found 12/9$493
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:15 pmMCI - GCM
1 stop18h 30mMultiple Airlines
Sun 1/42:40 pmGCM - MCI
2 stops20h 28mMultiple Airlines
Deal found 12/9$517
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:15 pmMCI - GCM
1 stop18h 30mSpirit Airlines
Sat 1/35:56 pmGCM - MCI
1 stop24h 14mSpirit Airlines
Deal found 12/9$549
This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:43 amMCI - GCM
1 stop7h 44mDelta
Thu 1/13:42 pmGCM - MCI
1 stop6h 38mDelta
Deal found 12/10$594
This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/217:05 amMCI - GCM
1 stop6h 22mDelta
Fri 12/263:42 pmGCM - MCI
1 stop7h 45mDelta
Deal found 12/10$664
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:33 amMCI - GCM
2 stops23h 02mMultiple Airlines
Sat 1/35:56 pmGCM - MCI
1 stop24h 14mMultiple Airlines
Deal found 12/9$667
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:15 pmMCI - GCM
2 stops20h 50mMultiple Airlines
Thu 12/252:40 pmGCM - MCI
1 stop27h 30mMultiple Airlines
Deal found 12/11$671
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:05 amMCI - GCM
2 stops14h 13mAmerican Airlines
Sun 12/283:45 pmGCM - MCI
1 stop10h 09mAmerican Airlines
Deal found 12/11$699
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2311:24 amMCI - GCM
2 stops27h 36mUnited Airlines
Thu 1/15:45 pmGCM - MCI
2 stops26h 57mUnited Airlines
Deal found 12/10$709
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/217:46 pmMCI - GCM
2 stops15h 04mAmerican Airlines
Fri 12/263:35 pmGCM - MCI
1 stop9h 13mAmerican Airlines
Deal found 12/11$744

Find flight deals from Missouri to Cayman Islands

Keep the following information in mind while searching for Missouri to Cayman Islands flight deals. Data was last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$296
(Kiwi.com)

One-way from

$149
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$662
Provider with most accurate pricing for Lambert-St Louis-George Town Owen Roberts Intl flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-George Town Owen Roberts Intl flights.
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From Missouri to Cayman Islands
Search Deals
One-way flight from Missouri to Cayman Islands
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($69 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Missouri to the Cayman Islands that are best for you.

Fly from

Missouri

Fly to

Cayman Islands

Route

Depart

Return

Price

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Wed 1/7

3:47 pm-1:53 pm

2 stops21h 06m

George Town Owen Roberts Intl

Sat 1/17

2:34 pm-10:31 am

1 stop20h 57m

$344

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Mon 1/26

6:00 am-12:40 pm

1 stop5h 40m

George Town Owen Roberts Intl

Tue 2/3

2:05 pm-8:37 pm

1 stop7h 32m

$352

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Wed 1/28

6:00 am-12:40 pm

1 stop5h 40m

George Town Owen Roberts Intl

Tue 2/3

2:05 pm-8:37 pm

1 stop7h 32m

$352

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Thu 1/8

6:30 am-1:45 pm

1 stop6h 15m

George Town Owen Roberts Intl

Thu 1/15

2:25 pm-11:59 pm

1 stop10h 34m

$375

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Fri 1/23

3:45 pm-12:50 pm

2 stops20h 05m

George Town Owen Roberts Intl

Tue 2/3

2:05 pm-11:37 pm

1 stop10h 32m

$375

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Mon 1/26

6:00 am-12:40 pm

1 stop5h 40m

George Town Owen Roberts Intl

Mon 2/2

2:05 pm-8:37 pm

1 stop7h 32m

$375

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sat 1/24

6:00 am-12:40 pm

1 stop5h 40m

George Town Owen Roberts Intl

Tue 2/3

2:05 pm-8:37 pm

1 stop7h 32m

$375

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Wed 1/28

6:00 am-12:40 pm

1 stop5h 40m

George Town Owen Roberts Intl

Sat 1/31

2:05 pm-7:27 pm

1 stop6h 22m

$375

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sat 1/31

6:00 am-2:00 pm

1 stop7h 00m

George Town Owen Roberts Intl

Fri 2/13

1:54 pm-11:36 pm

1 stop10h 42m

$383

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Thu 1/8

8:13 am-8:20 pm

2 stops11h 07m

George Town Owen Roberts Intl

Thu 1/15

3:45 pm-8:51 am

2 stops18h 06m

$388

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 24 results
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Best time to book a flight from Missouri to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to the Cayman Islands

What is the cheapest month to book a flight from Missouri to Cayman Islands?

Currently, May is the cheapest month in which you can book a flight from Missouri to Cayman Islands (average of $239). Flying from Missouri to Cayman Islands in December is currently the most expensive (average of $528). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to KY?

Find hourly flight availability from Missouri to Cayman Islands. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

When flying from Missouri to Cayman Islands, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 26% versus a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Cayman Islands?

    Departing from Missouri to Cayman Islands will take you 5h 40m. The distance between Missouri and Cayman Islands is about 1448 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Missouri to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Missouri to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Cayman Islands.

  • Can I find deals for business class flights from Missouri to Cayman Islands?

    Yes. Cheapflights offers flight deals from Missouri to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Cayman Islands?

    Currently, May is the cheapest month in which you can book a flight from Missouri to Cayman Islands (average of $239). Flying from Missouri to Cayman Islands in December is currently the most expensive (average of $528). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Cayman Islands

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Missouri to Cayman Islands

Discover the top 4 airlines that operate flights from Missouri to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$238Average$630FlexibilityNo cancel feeOn-time69%
DeltaCheapest$266Average$587FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$424Average$574FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$429Average$581FlexibilityNo cancel feeOn-time63%

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