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$86+ Cheap flights from South Carolina to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/15. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BUF
Apr 27 — May 41
Sun 4/27
Sun 5/4
1 adult, Economy
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Cheap flight deals from South Carolina to Buffalo

Keep the following information in mind while searching for South Carolina to Buffalo flight deals. Data was last updated April 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$160
(CheapOair)

One-way from

$86
(Frontier)

Popular in

February

Cheapest in

September

Average price

$440
Provider with most accurate pricing for Myrtle Beach Intl-Buffalo flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Buffalo flights.
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From South Carolina to Buffalo
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One-way flight from South Carolina to Buffalo
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Highest demand for flights based on searches. 3% potential increase in price ($13 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from South Carolina to Buffalo

Cheapest flights from South Carolina to Buffalo
Explore the most affordable flight options available from South Carolina to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

This CheapOair deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/164:21 pmCLT - BUF
1 stop18h 27mFrontier
Sat 5/174:59 pmBUF - CLT
1 stop23h 40mFrontier
Deal found 4/21$161
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/248:35 pmGSP - BUF
1 stop3h 39mAmerican Airlines
Thu 5/297:11 pmBUF - GSP
1 stop4h 39mAmerican Airlines
Deal found 4/22$217
This JetBlue deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/246:59 pmCHS - BUF
1 stop5h 00mJetBlue
Sun 6/299:45 amBUF - CHS
1 stop8h 19mJetBlue
Deal found 4/20$223
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/305:55 pmCAE - BUF
1 stop6h 00mDelta
Mon 6/26:00 amBUF - CAE
1 stop4h 44mDelta
Deal found 4/21$227
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/157:40 amSAV - BUF
1 stop5h 32mAmerican Airlines
Sun 5/187:11 pmBUF - SAV
1 stop4h 45mAmerican Airlines
Deal found 4/22$229
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/226:09 pmCHS - BUF
1 stop6h 05mAmerican Airlines
Sun 5/256:10 amBUF - CHS
1 stop4h 35mAmerican Airlines
Deal found 4/21$235
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/226:33 pmGSP - BUF
1 stop4h 13mDelta
Sun 5/251:00 pmBUF - GSP
1 stop4h 53mDelta
Deal found 4/22$252
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2410:28 pmCLT - BUF
Nonstop1h 46mAmerican Airlines
Wed 5/2812:01 pmBUF - CLT
Nonstop1h 55mAmerican Airlines
Deal found 4/22$253
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/74:00 pmHHH - BUF
1 stop7h 13mDelta
Sun 5/116:05 amBUF - HHH
1 stop5h 16mDelta
Deal found 4/21$259
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/17:59 pmCHS - BUF
1 stop4h 00mDelta
Sat 9/612:09 pmBUF - CHS
1 stop4h 46mDelta
Deal found 4/22$271
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/185:51 pmCLT - BUF
1 stop5h 29mDelta
Tue 6/2410:38 amBUF - CLT
1 stop5h 29mDelta
Deal found 4/21$273
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/75:30 pmMYR - BUF
1 stop5h 16mDelta
Sat 6/146:04 amBUF - MYR
1 stop5h 29mDelta
Deal found 4/22$287

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2025.
Use the filters below to find and compare flights from South Carolina to Buffalo that are best for you.

Fly from

South Carolina

Fly to

Buffalo

Route

Depart

Return

Price

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Fri 5/16

4:21 pm-10:48 am

1 stop18h 27m

Buffalo

Sat 5/17

4:59 pm-4:39 pm

1 stop23h 40m

$161

GreenvilleBuffalo

GSP - BUF

GSPBUF

Greenville

Sat 5/24

8:35 pm-12:14 am

1 stop3h 39m

Buffalo

Thu 5/29

7:11 pm-11:50 pm

1 stop4h 39m

$217

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Tue 6/24

6:59 pm-11:59 pm

1 stop5h 00m

Buffalo

Sun 6/29

9:45 am-6:04 pm

1 stop8h 19m

$223

ColumbiaBuffalo

CAE - BUF

CAEBUF

Columbia Metropolitan

Fri 5/30

5:55 pm-11:55 pm

1 stop6h 00m

Buffalo

Mon 6/2

6:00 am-10:44 am

1 stop4h 44m

$227

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Thu 5/15

7:40 am-1:12 pm

1 stop5h 32m

Buffalo

Sun 5/18

7:11 pm-11:56 pm

1 stop4h 45m

$229

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Thu 5/22

6:09 pm-12:14 am

1 stop6h 05m

Buffalo

Sun 5/25

6:10 am-10:45 am

1 stop4h 35m

$235

GreenvilleBuffalo

GSP - BUF

GSPBUF

Greenville

Thu 5/22

6:33 pm-10:46 pm

1 stop4h 13m

Buffalo

Sun 5/25

1:00 pm-5:53 pm

1 stop4h 53m

$252

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Sat 5/24

10:28 pm-12:14 am

Nonstop1h 46m

Buffalo

Wed 5/28

12:01 pm-1:56 pm

Nonstop1h 55m

$253

Hilton Head IslandBuffalo

HHH - BUF

HHHBUF

Hilton Head Island

Wed 5/7

4:00 pm-11:13 pm

1 stop7h 13m

Buffalo

Sun 5/11

6:05 am-11:21 am

1 stop5h 16m

$259

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Mon 9/1

7:59 pm-11:59 pm

1 stop4h 00m

Buffalo

Sat 9/6

12:09 pm-4:55 pm

1 stop4h 46m

$271

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/21

Showing 1-10 of 55 results
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Best time to book a flight from South Carolina to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Buffalo

What is the cheapest month to book a flight from South Carolina to Buffalo?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Buffalo (average of $256). Flying from South Carolina to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to BUF?

Find hourly flight availability from South Carolina to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 22, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Buffalo as you normally would.

Rainfall in Buffalo by month

Plan your trip to Buffalo by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Buffalo ranges from 2.5 - 4.0 inches per month. November is typically the wettest month, when rainfall can reach 4.0 in. February is typically the driest time to visit Buffalo when rainfall is around 2.5 in.

Temperature in Buffalo by month

Plan your trip to Buffalo by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Buffalo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 24.8 F).

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated April 22, 2025.
To help decide which airline to fly from South Carolina to Buffalo, see what other customers have to say about Southwest, Delta and United Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,286 reviews

Crew

8.6

Boarding

8.2

Entertainment

7.6

Comfort

8.0

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,286 reviews
Southwest
8.0
Very good
4,286 reviews

Crew

8.6

Boarding

8.2

Entertainment

7.6

Comfort

8.0

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,920 reviews
Southwest
8.0
Very good
4,286 reviews

Crew

8.6

Boarding

8.2

Entertainment

7.6

Comfort

8.0

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,683 reviews
Southwest
8.0
Very good
4,286 reviews

Crew

8.6

Boarding

8.2

Entertainment

7.6

Comfort

8.0

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
JetBlue
7.3
Good
2,923 reviews
Southwest
8.0
Very good
4,286 reviews

Crew

8.6

Boarding

8.2

Entertainment

7.6

Comfort

8.0

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,286 reviews

Crew

8.6

Boarding

8.2

Entertainment

7.6

Comfort

8.0

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from South Carolina?

    Most people fly into Buffalo (BUF) if they book a flight to Buffalo from South Carolina. Buffalo is conveniently located just 8.3 mi from Buffalo’s city center.

  • What are the cheapest airlines to fly from South Carolina to Buffalo one-way?

    $86 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $115 and $122, respectively.

  • What are the most popular routes from South Carolina to Buffalo?

    The most popular flight routes from South Carolina to Buffalo are Charlotte Douglas - Buffalo, Greenville - Buffalo and Savannah/Hilton Head - Buffalo.

  • Can I find deals for flights from South Carolina to Buffalo that include hotel bookings?

    Yes. In addition to deals on South Carolina to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Buffalo.

  • Can I find deals for business class flights from South Carolina to Buffalo?

    Yes. Cheapflights offers flight deals from South Carolina to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Buffalo (average of $256). Flying from South Carolina to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
West Seneca
Williamsville
Amherst
Batavia
Orchard Park
Cheektowaga

Browse thousands of different options on Cheapflights for your next trip

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Top 5 airlines flying from South Carolina to Buffalo

Discover the top 5 airlines that operate flights from South Carolina to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$197Average$349FlexibilityNo cancel feeOn-time71%
DeltaCheapest$201Average$305FlexibilityNo cancel feeOn-timeN/A
JetBlueCheapest$201Average$264FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$202Average$370FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$233Average$371FlexibilityNo cancel feeOn-time63%

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