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$115+ Cheap flights from South Carolina to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BUF
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from South Carolina to Buffalo

Keep the following information in mind while searching for South Carolina to Buffalo flight deals. Data was last updated February 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$183
(JetBlue)

One-way from

$115
(Delta)

Popular in

February

Cheapest in

September

Average price

$441
Provider with most accurate pricing for Myrtle Beach Intl-Buffalo flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Buffalo flights.
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From South Carolina to Buffalo
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One-way flight from South Carolina to Buffalo
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Highest demand for flights based on searches. 7% potential increase in price ($29 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Find flight deals from South Carolina to Buffalo

Cheapest flights from South Carolina to Buffalo
Explore the most affordable flight options available from South Carolina to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This JetBlue deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/312:30 pmCHS - BUF
1 stop6h 34mJetBlue
Mon 4/710:39 amBUF - CHS
1 stop5h 48mJetBlue
Deal found 2/20$183
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/107:39 pmGSP - BUF
1 stop4h 18mAmerican Airlines
Fri 3/145:30 amBUF - GSP
1 stop4h 26mAmerican Airlines
Deal found 2/20$199
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/37:50 pmSAV - BUF
1 stop4h 15mSouthwest
Mon 4/76:00 amBUF - SAV
1 stop4h 25mSouthwest
Deal found 2/19$199
This eDestinos deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/810:36 pmCLT - BUF
1 stop10h 25mFrontier
Sun 5/117:07 pmBUF - CLT
1 stop13h 50mFrontier
Deal found 2/19$200
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/178:24 pmSAV - BUF
1 stop3h 51mAmerican Airlines
Tue 5/207:21 pmBUF - SAV
1 stop4h 36mAmerican Airlines
Deal found 2/19$214
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/247:55 pmSAV - BUF
1 stop4h 12mDelta
Fri 3/287:48 pmBUF - SAV
1 stop20h 37mDelta
Deal found 2/18$236
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/34:35 pmCLT - BUF
Nonstop1h 43mAmerican Airlines
Mon 4/76:10 amBUF - CLT
Nonstop1h 57mAmerican Airlines
Deal found 2/19$247
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/125:11 pmCAE - BUF
1 stop5h 34mAmerican Airlines
Sat 5/176:00 amBUF - CAE
1 stop4h 43mAmerican Airlines
Deal found 2/20$249
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/78:55 amCHS - BUF
1 stop3h 30mSouthwest
Wed 5/144:15 pmBUF - CHS
1 stop4h 00mSouthwest
Deal found 2/19$257
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/910:59 amCLT - BUF
1 stop4h 21mDelta
Tue 3/116:22 amBUF - CLT
1 stop5h 41mDelta
Deal found 2/20$263
This Southwest deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/68:15 pmCLT - BUF
1 stop3h 50mSouthwest
Mon 3/106:00 amBUF - CLT
1 stop4h 00mSouthwest
Deal found 2/20$267
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/286:10 amCHS - BUF
1 stop16h 49mDelta
Mon 6/26:50 pmBUF - CHS
1 stop4h 50mDelta
Deal found 2/20$270

Find flights from South Carolina to Buffalo within your budget

Customize your flight search to find flights from South Carolina to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

South Carolina

Fly to

Buffalo

Route

Depart

Return

Price

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Thu 4/3

12:30 pm-7:04 pm

1 stop6h 34m

Buffalo

Mon 4/7

10:39 am-4:27 pm

1 stop5h 48m

$183

GreenvilleBuffalo

GSP - BUF

GSPBUF

Greenville

Mon 3/10

7:39 pm-11:57 pm

1 stop4h 18m

Buffalo

Fri 3/14

5:30 am-9:56 am

1 stop4h 26m

$199

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Thu 4/3

7:50 pm-12:05 am

1 stop4h 15m

Buffalo

Mon 4/7

6:00 am-10:25 am

1 stop4h 25m

$199

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Thu 5/8

10:36 pm-9:01 am

1 stop10h 25m

Buffalo

Sun 5/11

7:07 pm-8:57 am

1 stop13h 50m

$200

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Sat 5/17

8:24 pm-12:15 am

1 stop3h 51m

Buffalo

Tue 5/20

7:21 pm-11:57 pm

1 stop4h 36m

$214

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Mon 3/24

7:55 pm-12:07 am

1 stop4h 12m

Buffalo

Fri 3/28

7:48 pm-4:25 pm

1 stop20h 37m

$236

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Thu 4/3

4:35 pm-6:18 pm

Nonstop1h 43m

Buffalo

Mon 4/7

6:10 am-8:07 am

Nonstop1h 57m

$247

ColumbiaBuffalo

CAE - BUF

CAEBUF

Columbia Metropolitan

Mon 5/12

5:11 pm-10:45 pm

1 stop5h 34m

Buffalo

Sat 5/17

6:00 am-10:43 am

1 stop4h 43m

$249

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Wed 5/7

8:55 am-12:25 pm

1 stop3h 30m

Buffalo

Wed 5/14

4:15 pm-8:15 pm

1 stop4h 00m

$257

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Sun 3/9

10:59 am-3:20 pm

1 stop4h 21m

Buffalo

Tue 3/11

6:22 am-12:03 pm

1 stop5h 41m

$263

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/18

Showing 1-10 of 53 results
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Best time to book a flight from South Carolina to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from South Carolina to Buffalo

Get recent, data-driven insights about flights from South Carolina to Buffalo including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from South Carolina to Buffalo?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Buffalo (average of $256). Flying from South Carolina to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to BUF?

Find hourly flight availability from South Carolina to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Buffalo as you normally would.

Rainfall in Buffalo by month

Plan your trip to Buffalo by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Buffalo ranges from 2.5 - 4.0 inches per month. November is typically the wettest month, when rainfall can reach 4.0 in. February is typically the driest time to visit Buffalo when rainfall is around 2.5 in.

Temperature in Buffalo by month

Plan your trip to Buffalo by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Buffalo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 24.8 F).

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated February 20, 2025.
To help decide which airline to fly from South Carolina to Buffalo, see what other customers have to say about Southwest, Delta and JetBlue. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Comfort

8.1

Entertainment

7.6

Overall

8.1

Boarding

8.2

Food

7.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Southwest
8.1
Very good
4,411 reviews
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Comfort

8.1

Entertainment

7.6

Overall

8.1

Boarding

8.2

Food

7.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Delta
8.0
Very good
8,220 reviews
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Comfort

8.1

Entertainment

7.6

Overall

8.1

Boarding

8.2

Food

7.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

JetBlue
7.4
Good
3,070 reviews
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Comfort

8.1

Entertainment

7.6

Overall

8.1

Boarding

8.2

Food

7.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

United Airlines
7.4
Good
8,766 reviews
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Comfort

8.1

Entertainment

7.6

Overall

8.1

Boarding

8.2

Food

7.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Comfort

8.1

Entertainment

7.6

Overall

8.1

Boarding

8.2

Food

7.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from South Carolina?

    Most people fly into Buffalo (BUF) if they book a flight to Buffalo from South Carolina. Buffalo is conveniently located just 8.3 mi from Buffalo’s city center.

  • What are the cheapest airlines to fly from South Carolina to Buffalo one-way?

    $115 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and Southwest, with prices starting from $124 and $129, respectively.

  • What are the most popular routes from South Carolina to Buffalo?

    The most popular flight routes from South Carolina to Buffalo are Charlotte Douglas - Buffalo, Myrtle Beach Intl - Buffalo and Greenville - Buffalo.

  • Can I find deals for flights from South Carolina to Buffalo that include hotel bookings?

    Yes. In addition to deals on South Carolina to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Buffalo.

  • Can I find deals for business class flights from South Carolina to Buffalo?

    Yes. Cheapflights offers flight deals from South Carolina to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Buffalo (average of $256). Flying from South Carolina to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
West Seneca
Williamsville
Amherst
Batavia
Orchard Park
Cheektowaga

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Top 5 airlines flying from South Carolina to Buffalo

Discover the top 5 airlines that operate flights from South Carolina to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$197Average$352FlexibilityNo cancel feeOn-time71%
JetBlueCheapest$201Average$290FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$202Average$379FlexibilityNo cancel feeOn-time69%
DeltaCheapest$207Average$317FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$233Average$401FlexibilityNo cancel feeOn-time63%
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