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$136+ Cheap flights from Iowa to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/5. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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Cheap flight deals from Iowa to Buffalo

Keep the following information in mind while searching for Iowa to Buffalo flight deals. Data was last updated April 17, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(American Airlines)

One-way from

$136
(American Airlines)

Popular in

December

Cheapest in

November

Average price

$694
Provider with most accurate pricing for Des Moines-Buffalo flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Buffalo flights.
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From Iowa to Buffalo
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One-way flight from Iowa to Buffalo
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Highest demand for flights based on searches. 10% potential increase in price ($55 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($26 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Iowa to Buffalo

Cheapest flights from Iowa to Buffalo
Explore the most affordable flight options available from Iowa to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/144:25 pmMLI - BUF
1 stop6h 49mAmerican Airlines
Sun 5/185:10 amBUF - MLI
1 stop6h 32mAmerican Airlines
Deal found 4/17$249
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/75:15 pmMLI - BUF
1 stop5h 41mDelta
Tue 6/102:16 pmBUF - MLI
2 stops9h 31mDelta
Deal found 4/17$254
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/214:00 pmOMA - BUF
1 stop4h 05mSouthwest
Wed 6/47:20 pmBUF - OMA
1 stop4h 10mSouthwest
Deal found 4/17$271
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/35:50 pmDSM - BUF
1 stop3h 56mDelta
Sat 6/76:30 amBUF - DSM
1 stop4h 07mDelta
Deal found 4/16$284
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/126:14 pmOMA - BUF
1 stop5h 00mAmerican Airlines
Tue 5/136:00 pmBUF - OMA
1 stop5h 37mAmerican Airlines
Deal found 4/17$287
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/410:07 amDSM - BUF
2 stops7h 56mAmerican Airlines
Tue 7/85:00 pmBUF - DSM
1 stop4h 35mAmerican Airlines
Deal found 4/15$289
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/92:00 pmOMA - BUF
1 stop3h 54mDelta
Sun 7/136:30 amBUF - OMA
1 stop3h 59mDelta
Deal found 4/17$332
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/33:38 pmDSM - BUF
1 stop4h 23mUnited Airlines
Sat 6/75:51 pmBUF - DSM
1 stop4h 31mUnited Airlines
Deal found 4/16$364
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2111:30 amOMA - BUF
2 stops11h 06mUnited Airlines
Tue 5/275:51 pmBUF - OMA
1 stop5h 09mUnited Airlines
Deal found 4/17$430
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/233:45 pmMLI - BUF
1 stop4h 16mUnited Airlines
Fri 7/255:54 pmBUF - MLI
1 stop4h 43mUnited Airlines
Deal found 4/17$550
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2211:25 amCID - BUF
1 stop4h 30mUnited Airlines
Sat 4/261:55 pmBUF - CID
1 stop3h 56mUnited Airlines
Deal found 4/17$558
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/222:55 pmCID - BUF
2 stops8h 36mAmerican Airlines
Sat 4/2612:35 pmBUF - CID
2 stops6h 38mAmerican Airlines
Deal found 4/17$649

Cheapflights Fare Finder

Customize your flight search to find flights from Iowa to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from Iowa to Buffalo that are best for you.

Fly from

Iowa

Fly to

Buffalo

Route

Depart

Return

Price

MolineBuffalo

MLI - BUF

MLIBUF

Moline Quad-City

Wed 5/14

4:25 pm-12:14 am

1 stop6h 49m

Buffalo

Sun 5/18

5:10 am-10:42 am

1 stop6h 32m

$249

MolineBuffalo

MLI - BUF

MLIBUF

Moline Quad-City

Sat 6/7

5:15 pm-11:56 pm

1 stop5h 41m

Buffalo

Tue 6/10

2:16 pm-10:47 pm

2 stops9h 31m

$254

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Wed 5/21

4:00 pm-9:05 pm

1 stop4h 05m

Buffalo

Wed 6/4

7:20 pm-10:30 pm

1 stop4h 10m

$271

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Tue 6/3

5:50 pm-10:46 pm

1 stop3h 56m

Buffalo

Sat 6/7

6:30 am-9:37 am

1 stop4h 07m

$284

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Mon 5/12

6:14 pm-12:14 am

1 stop5h 00m

Buffalo

Tue 5/13

6:00 pm-10:37 pm

1 stop5h 37m

$287

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 7/4

10:07 am-7:03 pm

2 stops7h 56m

Buffalo

Tue 7/8

5:00 pm-8:35 pm

1 stop4h 35m

$289

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Wed 7/9

2:00 pm-6:54 pm

1 stop3h 54m

Buffalo

Sun 7/13

6:30 am-9:29 am

1 stop3h 59m

$332

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Tue 6/3

3:38 pm-9:01 pm

1 stop4h 23m

Buffalo

Sat 6/7

5:51 pm-9:22 pm

1 stop4h 31m

$364

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Wed 5/21

11:30 am-11:36 pm

2 stops11h 06m

Buffalo

Tue 5/27

5:51 pm-10:00 pm

1 stop5h 09m

$430

MolineBuffalo

MLI - BUF

MLIBUF

Moline Quad-City

Wed 7/23

3:45 pm-9:01 pm

1 stop4h 16m

Buffalo

Fri 7/25

5:54 pm-9:37 pm

1 stop4h 43m

$550

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/17

Showing 1-10 of 18 results
1
2

Best time to book a flight from Iowa to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Buffalo

What is the cheapest month to book a flight from Iowa to Buffalo?

Currently, January is the cheapest month in which you can book a flight from Iowa to Buffalo (average of $256). Flying from Iowa to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Buffalo by month

Plan your trip to Buffalo by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Buffalo ranges from 2.5 - 4.0 inches per month. November is typically the wettest month, when rainfall can reach 4.0 in. February is typically the driest time to visit Buffalo when rainfall is around 2.5 in.

Temperature in Buffalo by month

Plan your trip to Buffalo by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Buffalo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 24.8 F).

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated April 17, 2025.
To help decide which airline to fly from Iowa to Buffalo, see what other customers have to say about Southwest, Delta and United Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Overall

8.0

Food

7.1

Crew

8.6

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.0
Very good
4,280 reviews
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Overall

8.0

Food

7.1

Crew

8.6

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,917 reviews
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Overall

8.0

Food

7.1

Crew

8.6

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,667 reviews
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Overall

8.0

Food

7.1

Crew

8.6

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Overall

8.0

Food

7.1

Crew

8.6

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Iowa?

    Most people fly into Buffalo (BUF) if they book a flight to Buffalo from Iowa. Buffalo is conveniently located just 8.3 mi from Buffalo’s city center.

  • What are the cheapest airlines to fly from Iowa to Buffalo one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $136. Users have also found prices from $184 and $285 on Delta and United Airlines, respectively.

  • What are the most popular routes from Iowa to Buffalo?

    While some choose either Des Moines - Buffalo or Moline Quad-City - Buffalo, Omaha Eppley Airfield - Buffalo is the most popular route from Iowa to Buffalo.

  • Can I find deals for flights from Iowa to Buffalo that include hotel bookings?

    Yes. In addition to deals on Iowa to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Buffalo.

  • Can I find deals for business class flights from Iowa to Buffalo?

    Yes. Cheapflights offers flight deals from Iowa to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Iowa to Buffalo (average of $256). Flying from Iowa to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Iowa?

Book flights to Iowa if you plan to visit one of these locations
West Seneca
Williamsville
Amherst
Batavia
Orchard Park
Cheektowaga

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Alternative routes for Iowa to Buffalo

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Top 3 airlines flying from Iowa to Buffalo

Discover the top 3 airlines that operate flights from Iowa to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$196Average$346FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$350FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$260Average$481FlexibilityNo cancel feeOn-time69%

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