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$502+ Cheap flights from South Carolina to Brussels

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BRU
Apr 27 — May 41
Sun 4/27
Sun 5/4
1 adult, Economy
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Cheap flight deals from South Carolina to Brussels

Keep the following information in mind while searching for South Carolina to Brussels flight deals. Data was last updated April 22, 2025.

Round-trip from

$644
(United Airlines)

One-way from

$502
(Kiwi.com)
From South Carolina to Brussels
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One-way flight from South Carolina to Brussels
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Find flight deals from South Carolina to Brussels

Cheapest flights from South Carolina to Brussels
Explore the most affordable flight options available from South Carolina to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:00 amCHS - BRU
2 stops19h 55mUnited Airlines
Tue 12/210:00 amBRU - CHS
2 stops35h 24mUnited Airlines
Deal found 4/22$621
This Air Canada deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/299:20 amCLT - BRU
2 stops40h 35mAir Canada
Tue 12/910:00 amBRU - CLT
2 stops36h 19mAir Canada
Deal found 4/21$632
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/297:30 pmCLT - BRU
1 stop31h 30mDelta
Tue 12/911:00 amBRU - CLT
1 stop17h 07mDelta
Deal found 4/21$639
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1310:58 amMYR - BRU
2 stops15h 02mUnited Airlines
Tue 8/268:45 amBRU - MYR
1 stop13h 34mUnited Airlines
Deal found 4/22$644
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/242:30 pmCHS - BRU
1 stop12h 30mDelta
Tue 12/211:00 amBRU - CHS
1 stop17h 26mDelta
Deal found 4/21$644
This Scandinavian Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Scandinavian Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/310:00 amCLT - BRU
2 stops23h 20mScandinavian Airlines
Wed 9/1010:20 amBRU - CLT
2 stops17h 47mScandinavian Airlines
Deal found 4/22$649
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/282:30 pmCLT - BRU
1 stop11h 35mUnited Airlines
Tue 12/910:00 amBRU - CLT
2 stops32h 48mUnited Airlines
Deal found 4/21$661
This Air Canada deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/710:58 amMYR - BRU
2 stops15h 02mAir Canada
Wed 8/2010:00 amBRU - MYR
2 stops36h 19mAir Canada
Deal found 4/22$671
This Cheapflightsfares deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/83:40 pmCLT - BRU
1 stop21h 15mIberia
Wed 9/177:05 amBRU - CLT
1 stop15h 00mIberia
Deal found 4/21$686
This Scandinavian Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Scandinavian Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/202:15 pmMYR - BRU
2 stops22h 15mScandinavian Airlines
Tue 9/28:30 pmBRU - MYR
2 stops33h 09mScandinavian Airlines
Deal found 4/22$691
This Air France deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/31:10 pmCLT - BRU
1 stop13h 30mAir France
Wed 9/1010:45 amBRU - CLT
1 stop12h 47mAir France
Deal found 4/22$699
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/95:00 pmMYR - BRU
2 stops33h 30mDelta
Sat 8/2310:45 amBRU - MYR
1 stop31h 14mDelta
Deal found 4/22$716

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2025.
Use the filters below to find and compare flights from South Carolina to Brussels that are best for you.

Fly from

South Carolina

Fly to

Brussels

Route

Depart

Return

Price

Myrtle BeachBrussels

MYR - BRU

MYRBRU

Myrtle Beach Intl

Wed 8/13

10:58 am-8:00 am

2 stops15h 02m

Brussels Bruxelles-National

Tue 8/26

8:45 am-4:19 pm

1 stop13h 34m

$644

Myrtle BeachBrussels

MYR - BRU

MYRBRU

Myrtle Beach Intl

Thu 8/7

10:58 am-8:00 am

2 stops15h 02m

Brussels Bruxelles-National

Wed 8/20

10:00 am-4:19 pm

2 stops36h 19m

$671

Myrtle BeachBrussels

MYR - BRU

MYRBRU

Myrtle Beach Intl

Wed 8/20

2:15 pm-6:30 pm

2 stops22h 15m

Brussels Bruxelles-National

Tue 9/2

8:30 pm-11:39 pm

2 stops33h 09m

$691

CharlotteBrussels

CLT - BRU

CLTBRU

Charlotte Douglas

Mon 5/12

7:40 pm-8:05 am

2 stops30h 25m

Brussels Bruxelles-National

Wed 5/28

10:00 am-2:31 pm

2 stops34h 31m

$713

Myrtle BeachBrussels

MYR - BRU

MYRBRU

Myrtle Beach Intl

Sat 8/9

5:00 pm-8:30 am

2 stops33h 30m

Brussels Bruxelles-National

Sat 8/23

10:45 am-11:59 am

1 stop31h 14m

$716

CharlotteBrussels

CLT - BRU

CLTBRU

Charlotte Douglas

Mon 5/12

10:24 am-7:15 am

1 stop14h 51m

Brussels Bruxelles-National

Wed 5/28

12:00 pm-6:52 pm

1 stop12h 52m

$747

CharlotteBrussels

CLT - BRU

CLTBRU

Charlotte Douglas

Wed 5/21

5:45 am-8:05 am

2 stops20h 20m

Brussels Bruxelles-National

Wed 5/28

10:00 am-10:28 am

2 stops30h 28m

$776

CharlotteBrussels

CLT - BRU

CLTBRU

Charlotte Douglas

Thu 5/8

10:24 am-7:25 am

1 stop15h 01m

Brussels Bruxelles-National

Tue 5/13

10:00 am-2:11 pm

2 stops34h 11m

$781

CharlestonBrussels

CHS - BRU

CHSBRU

Charleston

Thu 5/8

4:55 pm-8:05 am

2 stops33h 10m

Brussels Bruxelles-National

Tue 5/13

10:00 am-2:55 pm

2 stops34h 55m

$812

CharlestonBrussels

CHS - BRU

CHSBRU

Charleston

Thu 5/8

8:03 pm-8:40 am

2 stops30h 37m

Brussels Bruxelles-National

Tue 5/13

10:45 am-8:43 pm

1 stop15h 58m

$864

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/22

Showing 1-10 of 33 results
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Best time to book a flight from South Carolina to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Brussels

What is the cheapest time of day to fly from SC to BRU?

Find hourly flight availability from South Carolina to Brussels. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 22, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Brussels as you normally would.

Rainfall in Brussels by month

Plan your trip to Brussels by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Brussels ranges from 1.6 - 3.1 inches per month. January is typically the wettest month, when rainfall can reach 3.1 in. August is typically the driest time to visit Brussels when rainfall is around 1.6 in.

Temperature in Brussels by month

Plan your trip to Brussels by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Brussels, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 37.4 F).

Reviews of airlines servicing Brussels

Get insights into the airlines that provide service to Brussels. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Brussels. Reviews last updated April 22, 2025.
Read through reviews of airlines operating flights from South Carolina to Brussels, such as Delta, KLM and SWISS. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,920 reviews
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
KLM
7.8
Good
1,331 reviews
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
SWISS
7.5
Good
1,582 reviews
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,683 reviews
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Virgin Atlantic
7.4
Good
642 reviews
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from South Carolina to Brussels one-way?

    To fly one-way, consider booking your trip with Air Canada, which is currently one of the cheapest options available, starting at $534. KLM flights start at $538 while deals on Brussels Airlines start at $824 one-way.

  • What are the most popular routes from South Carolina to Brussels?

    While some choose either Charleston - Brussels Bruxelles-National or Columbia Metropolitan - Brussels Bruxelles-National, Charlotte Douglas - Brussels Bruxelles-National is the most popular route from South Carolina to Brussels.

  • Can I find deals for flights from South Carolina to Brussels that include hotel bookings?

    Yes. In addition to deals on South Carolina to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Brussels.

  • Can I find deals for business class flights from South Carolina to Brussels?

    Yes. Cheapflights offers flight deals from South Carolina to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Brussels?

    Currently, November is the cheapest month in which you can book a flight from South Carolina to Brussels (average of $614). Flying from South Carolina to Brussels in June is currently the most expensive (average of $1,146). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from South Carolina to Brussels

Discover the top airline that operate flights from South Carolina to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$551Average$1,051FlexibilityNo cancel feeOn-time69%

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